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通过 Purpurin-18-N-Propylimide 甲酯固态脂质纳米粒增强光动力疗法治疗癌症。

Enhanced Photodynamic Therapy Efficacy through Solid Lipid Nanoparticle of Purpurin-18-N-Propylimide Methyl Ester for Cancer Treatment.

机构信息

Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Republic of Korea.

Center for Nano Manufacturing and Department of Nanoscience and Engineering, Inje University, Gimhae 50834, Republic of Korea.

出版信息

Int J Mol Sci. 2024 Sep 26;25(19):10382. doi: 10.3390/ijms251910382.

DOI:10.3390/ijms251910382
PMID:39408712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11477127/
Abstract

Photodynamic therapy (PDT) is an innovative cancer treatment that utilizes light. When light irradiates, purpurin-18-N-propylimide methyl ester (P18 N PI ME) generates reactive oxygen species that destroy cancer cells. The hydrophobic nature of P18 N PI ME presents challenges regarding its aggregation in the body, which can affect its effectiveness. This study aimed to enhance the bioavailability and effectiveness of cancer treatment by synthesizing P18 N PI ME and formulating P18 N PI ME-loaded solid lipid nanoparticles (SLNs). The efficacy of PDT was estimated using the 1,3-diphenylisobenzofuran (DPBF) assay and photocytotoxicity tests on the HeLa (human cervical carcinoma) and A549 (human lung carcinoma) cell lines. The P18 N PI ME-loaded SLNs demonstrated particle sizes in the range of 158.59 nm to 248.43 nm and zeta potentials in the range of -15.97 mV to -28.73 mV. These SLNs exhibited sustained release of P18 N PI ME. DPBF analysis revealed enhanced PDT effects with SLNs containing P18 N PI ME compared with standalone P18 N PI MEs. Photocytotoxicity assays indicated toxicity under light irradiation but no toxicity in the dark. Furthermore, the smallest-sized formulation exhibited the most effective photodynamic activity. These findings indicate the potential of P18 N PI ME-loaded SLNs as promising strategies for PDT in cancer therapy.

摘要

光动力疗法（PDT）是一种利用光的创新癌症治疗方法。当光照射时，卟啉-18-N-丙基酰亚胺甲酯（P18 N PI ME）会产生破坏癌细胞的活性氧物质。P18 N PI ME 的疏水性使其在体内容易聚集，从而影响其效果。本研究旨在通过合成 P18 N PI ME 并制备 P18 N PI ME 载固脂纳米粒（SLNs）来提高癌症治疗的生物利用度和效果。使用 1,3-二苯基异苯并呋喃（DPBF）测定法和 HeLa（人宫颈癌）和 A549（人肺癌）细胞系的光细胞毒性试验来评估 PDT 的疗效。P18 N PI ME 载 SLNs 的粒径在 158.59nm 至 248.43nm 之间，zeta 电位在-15.97mV 至-28.73mV 之间。这些 SLNs 表现出 P18 N PI ME 的持续释放。DPBF 分析表明，与单独的 P18 N PI ME 相比，含有 P18 N PI ME 的 SLNs 具有增强的 PDT 效果。光细胞毒性试验表明，在光照下具有毒性，但在黑暗中没有毒性。此外，最小粒径的制剂表现出最有效的光动力活性。这些发现表明 P18 N PI ME 载 SLNs 作为癌症治疗中 PDT 的有前途策略的潜力。

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本文引用的文献

1
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J Natl Cancer Cent. 2024 May 7;4(2):128-134. doi: 10.1016/j.jncc.2024.05.001. eCollection 2024 Jun.
2
Interaction of Serum and Plasma Proteins with Polyelectrolyte Microparticles with Core/Shell and Shell-Only Structures.血清和血浆蛋白与具有核/壳和仅壳结构的聚电解质微粒的相互作用。
ACS Omega. 2024 Jun 28;9(27):29739-29750. doi: 10.1021/acsomega.4c03307. eCollection 2024 Jul 9.
3
Saturated long chain fatty acids as possible natural alternative antibacterial agents: Opportunities and challenges.
饱和长链脂肪酸作为可能的天然抗菌剂替代品：机遇与挑战。
Adv Colloid Interface Sci. 2023 Aug;318:102952. doi: 10.1016/j.cis.2023.102952. Epub 2023 Jun 19.
4
Review of cancer therapies for the perioperative physician.围手术期医生的癌症治疗综述。
Perioper Med (Lond). 2023 Jun 13;12(1):25. doi: 10.1186/s13741-023-00315-1.
5
Antimicrobial photodynamic therapy in treatment of aggressive periodontitis (stage III, grade C periodontitis): A comparison between photodynamic therapy and antibiotic therapy as an adjunct to non-surgical periodontal treatment.抗菌光动力疗法治疗侵袭性牙周炎（III 期，C 级牙周炎）：光动力疗法与抗生素疗法作为非手术牙周治疗辅助手段的比较。
Photodiagnosis Photodyn Ther. 2023 Mar;41:103251. doi: 10.1016/j.pdpdt.2022.103251. Epub 2022 Dec 29.
6
Anti-lung cancer effect of paclitaxel solid lipid nanoparticles delivery system with curcumin as co-loading partner in vitro and in vivo.紫杉醇固体脂质纳米粒给药系统联合姜黄素共载药对肺癌的体内外抗瘤作用
Drug Deliv. 2022 Dec;29(1):1878-1891. doi: 10.1080/10717544.2022.2086938.
7
An Updated Review on EPR-Based Solid Tumor Targeting Nanocarriers for Cancer Treatment.基于电子顺磁共振的实体瘤靶向纳米载体用于癌症治疗的最新综述
Cancers (Basel). 2022 Jun 10;14(12):2868. doi: 10.3390/cancers14122868.
8
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Pharmaceutics. 2022 May 15;14(5):1064. doi: 10.3390/pharmaceutics14051064.
9
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Nanoscale Res Lett. 2022 Mar 8;17(1):33. doi: 10.1186/s11671-022-03674-8.
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Pharmaceutics. 2022 Jan 16;14(1):210. doi: 10.3390/pharmaceutics14010210.