Ali Kiran M, Huang Yihan, Amanah Alaowei Y, Mahmood Nasif, Suh Taylor C, Gluck Jessica M
Department of Textile Engineering, Chemistry and Science, Wilson College of Textiles, NC State University, Raleigh, NC 27695, USA.
Polymers (Basel). 2022 May 21;14(10):2100. doi: 10.3390/polym14102100.
Automation and mass-production are two of the many limitations in the tissue engineering industry. Textile fabrication methods such as electrospinning are used extensively in this field because of the resemblance of the extracellular matrix to the fiber structure. However, electrospinning has many limitations, including the ability to mass-produce, automate, and reproduce products. For this reason, this study evaluates the potential use of a traditional textile method such as spinning. Apart from mass production, these methods are also easy, efficient, and cost-effective. This study uses bovine-derived collagen fibers to create yarns using the traditional ring spinning method. The collagen yarns are proven to be biocompatible. Enzymatic biodegradability was also confirmed for its potential use in vivo. The results of this study prove the safety and efficacy of the material and the fabrication method. The material encourages higher cell proliferation and migration compared to tissue culture-treated plastic plates. The process is not only simple but is also streamlined and replicable, resulting in standardized products that can be reproduced.
自动化和大规模生产是组织工程行业诸多限制中的两个。诸如静电纺丝之类的纺织制造方法由于细胞外基质与纤维结构的相似性而在该领域被广泛使用。然而，静电纺丝有许多局限性，包括大规模生产、自动化以及产品复制的能力。因此，本研究评估了诸如纺纱等传统纺织方法的潜在用途。除了大规模生产外，这些方法还简便、高效且具有成本效益。本研究使用牛源胶原蛋白纤维，采用传统环锭纺方法来制造纱线。已证实胶原蛋白纱线具有生物相容性。还确认了其酶促生物降解性在体内的潜在用途。本研究结果证明了该材料及制造方法的安全性和有效性。与经组织培养处理的塑料板相比，该材料能促进更高的细胞增殖和迁移。该过程不仅简单，而且流程简化且可复制，从而产生可复制的标准化产品。
