Li Qiu, Guo Guangxing, Meng Fancheng, Wang Helena H, Niu Yiming, Zhang Qingwen, Zhang Junfeng, Wang Yitao, Dong Lei, Wang Chunming
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China.
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, China.
ACS Macro Lett. 2016 May 17;5(5):617-621. doi: 10.1021/acsmacrolett.6b00182. Epub 2016 May 3.
We herein report the discovery of a naturally derived carbohydrate with binding affinities for two pro-angiogenic growth factors-fibroblast growth factor-2 (FGF-2) and platelet-derived growth factor-BB (PDGF-BB). This galacturonic acid-containing polysaccharide (EUP3) sequestered endogenous FGF-2 and PDGF-BB in vivo and promoted in situ formation and maturation of new blood vessels. Our findings suggest EUP3 as the first nonglycosaminoglycan, nonanimal-originated carbohydrate molecule that binds two pro-angiogenic growth factors to stimulate angiogenesis. Further investigations into this carbohydrate may lead to the development of new tools for therapeutic angiogenesis.
我们在此报告发现了一种天然衍生的碳水化合物，它对两种促血管生成生长因子——成纤维细胞生长因子-2（FGF-2）和血小板衍生生长因子-BB（PDGF-BB）具有结合亲和力。这种含半乳糖醛酸的多糖（EUP3）在体内隔离内源性FGF-2和PDGF-BB，并促进新血管的原位形成和成熟。我们的研究结果表明，EUP3是首个结合两种促血管生成生长因子以刺激血管生成的非糖胺聚糖、非动物源碳水化合物分子。对这种碳水化合物的进一步研究可能会带来治疗性血管生成新工具的开发。
