Microbiology Department, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78210, Mexico.
Section of Molecular and Translational Medicine, Centro de Investigación de Ciencias de la Salud y Biomedicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78210, Mexico.
Viruses. 2022 May 16;14(5):1058. doi: 10.3390/v14051058.
Human metapneumovirus (HMPV) is an important respiratory pathogen and is divided in two main groups (A and B). HMPV strains with partial duplications (111-nt and 180-nt duplication) of the G gene have been reported in recent years. Since the initial reports, viruses with these characteristics have been reported in several countries. We analyzed all complete HMPV G gene ectodomain sequences available at GenBank to determine if viruses with 111-nt or 180-nt duplication have become the leading HMPV strains worldwide, and to describe their temporal and geographic distribution. We identified 1462 sequences that fulfilled study criteria (764 HMPV A and 698 HMPV B) reported from 37 countries. The most frequent HMPV A genotype was A2b2 ( = 366), and the most frequent B genotype was B2 ( = 374). A total of 84 sequences contained the 111-nt duplication, and 90 sequences contained the 180-nt duplication. Since 2016, viruses with a partial duplication comprise the most frequent HMPV A sequences globally and have displaced other HMPV A viruses in Asia, Europe, and South America; no sequences of viruses with partial duplication have been reported in North America or Africa so far. Continued surveillance of HMPV is required to identify the emergence and spread of epidemiologically relevant variants.
人偏肺病毒（HMPV）是一种重要的呼吸道病原体，可分为两个主要群组（A 和 B）。近年来，已有报道称 G 基因部分重复（111-nt 和 180-nt 重复）的 HMPV 株。自最初的报道以来，已有多个国家报告了具有这些特征的病毒。我们分析了 GenBank 中所有可用的完整 HMPV G 基因外显子序列，以确定具有 111-nt 或 180-nt 重复的病毒是否已成为全球主要的 HMPV 株，并描述其时间和地理分布。我们确定了 1462 条符合研究标准的序列（764 条 HMPV A 和 698 条 HMPV B），这些序列来自 37 个国家。最常见的 HMPV A 基因型是 A2b2（=366），最常见的 B 基因型是 B2（=374）。共有 84 个序列包含 111-nt 重复，90 个序列包含 180-nt 重复。自 2016 年以来，具有部分重复的病毒构成了全球最常见的 HMPV A 序列，并已取代了亚洲、欧洲和南美洲的其他 HMPV A 病毒；到目前为止，尚未在北美或非洲报告具有部分重复的病毒序列。需要继续监测 HMPV，以识别流行病学相关变异的出现和传播。
