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蔓越莓渣提取物以安全剂量作用于成年斑马鱼，对寨卡病毒和登革热病毒表现出抗病毒活性。

Cranberry Pomace Extract Exerts Antiviral Activity against Zika and Dengue Virus at Safe Doses for Adult Zebrafish.

机构信息

Unité Mixte Processus Infectieux En Milieu Insulaire Tropical, Université De La Réunion, INSERM U1187, CNRS UMR 9192, IRD UMR 249, Plateforme Technologique CYROI, 94791 Sainte Clotilde, France.

Department of Food Science and Technology, Kaunas University of Technology, Radvilenu, pl. 19, LT-50254 Kaunas, Lithuania.

出版信息

Viruses. 2022 May 20;14(5):1101. doi: 10.3390/v14051101.

DOI:10.3390/v14051101
PMID:35632841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9147401/
Abstract

Mosquito-borne dengue virus (DENV) and zika virus (ZIKV) infections constitute a global health emergency. Antivirals directly targeting the virus infectious cycle are still needed to prevent dengue hemorrhagic fever and congenital zika syndrome. In the present study, we demonstrated that Cranberry Pomace (CP) extract, a polyphenol-rich agrifood byproduct recovered following cranberry juice extraction, blocks DENV and ZIKV infection in human Huh7.5 and A549 cell lines, respectively, in non-cytotoxic concentrations. Our virological assays identified CP extract as a potential inhibitor of virus entry into the host-cell by acting directly on viral particles, thus preventing their attachment to the cell surface. At effective antiviral doses, CP extract proved safe and tolerable in a zebrafish model. In conclusion, polyphenol-rich agrifood byproducts such as berry extracts are a promising source of safe and naturally derived nutraceutical antivirals that target medically important pathogens.

摘要

蚊媒登革热病毒 (DENV) 和 Zika 病毒 (ZIKV) 感染构成了全球卫生紧急情况。仍然需要直接针对病毒感染周期的抗病毒药物来预防登革出血热和先天性 Zika 综合征。在本研究中，我们证明了蔓越莓渣 (CP) 提取物，一种在蔓越莓汁提取后回收的富含多酚的农业食品副产物，分别在非细胞毒性浓度下阻断了人 Huh7.5 和 A549 细胞系中的 DENV 和 ZIKV 感染。我们的病毒学研究表明，CP 提取物可通过直接作用于病毒颗粒来阻止病毒进入宿主细胞，从而防止其附着在细胞表面，从而成为一种有潜力的病毒进入抑制剂。在有效的抗病毒剂量下，CP 提取物在斑马鱼模型中被证明是安全且耐受的。总之，富含多酚的农业食品副产物，如浆果提取物，是一种有前途的安全且源自天然的营养抗病毒药物来源，可以针对具有重要医学意义的病原体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/837d/9147401/a257ae454428/viruses-14-01101-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/837d/9147401/24efa8fe106a/viruses-14-01101-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/837d/9147401/0842b362cf50/viruses-14-01101-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/837d/9147401/6e4083dd6264/viruses-14-01101-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/837d/9147401/aabfdd071e5d/viruses-14-01101-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/837d/9147401/585d8c7b4a7f/viruses-14-01101-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/837d/9147401/a257ae454428/viruses-14-01101-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/837d/9147401/24efa8fe106a/viruses-14-01101-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/837d/9147401/0842b362cf50/viruses-14-01101-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/837d/9147401/6e4083dd6264/viruses-14-01101-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/837d/9147401/aabfdd071e5d/viruses-14-01101-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/837d/9147401/585d8c7b4a7f/viruses-14-01101-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/837d/9147401/a257ae454428/viruses-14-01101-g006.jpg

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