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利用肠道转铁蛋白受体通过可调纳米平台进行蛋白质口服递送的非竞争性主动运输

Noncompetitive Active Transport Exploiting Intestinal Transferrin Receptors for Oral Delivery of Proteins by Tunable Nanoplatform.

作者信息

Ganugula Raghu, Arora Meenakshi, Guada Melissa, Saini Prabhjot, Kumar Majeti N V Ravi

机构信息

Department of Pharmaceutical Sciences, College of Pharmacy, Texas A&M University, Reynolds Medical Building, TAMU Mailstop 1114, College Station, Texas 77843, United States.

出版信息

ACS Macro Lett. 2017 Feb 21;6(2):161-164. doi: 10.1021/acsmacrolett.7b00035. Epub 2017 Feb 3.

DOI:10.1021/acsmacrolett.7b00035
PMID:35632886
Abstract

Here we present a "thinking-outside-the-box", tunable nanoplatform for oral delivery of proteins using insulin as a model protein. These nanosystems offer noncompetitive active transport exploiting transferrin receptors present in the intestine and permit tailored release in vivo. Such delivery approaches have the potential to individualize insulin therapy to a regimen that is compatible with the patient's glucose profile.

摘要

在此，我们展示了一种“跳出框框思考”的、可调节的纳米平台，用于以胰岛素作为模型蛋白进行口服蛋白质递送。这些纳米系统利用肠道中存在的转铁蛋白受体提供非竞争性主动转运，并允许在体内进行定制释放。这种递送方法有可能将胰岛素治疗个性化，使其成为与患者血糖状况相适应的方案。

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