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双头纳米系统用于口服药物递送。

Double-headed nanosystems for oral drug delivery.

机构信息

Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, TAMU Mailstop 1114, College Station, Texas 77843, USA.

出版信息

Chem Commun (Camb). 2019 Apr 18;55(33):4761-4764. doi: 10.1039/c8cc10021g.

DOI:10.1039/c8cc10021g
PMID:30869656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6472980/
Abstract

We demonstrate a novel strategy to engineer double-headed nanosystems by chemical modification of the carboxyl terminal polyester with a linker that offers tripodal arrangement of ligands on the particle surfaces. The in vivo results suggest that the bioavailability of encapsulated curcumin is proportional to the ligand density rendered by double-headed nanosystems.

摘要

我们展示了一种通过化学修饰羧基末端聚酯的新策略来构建双头纳米系统，该策略使用一个连接子在颗粒表面提供三足配体排列。体内实验结果表明，包封姜黄素的生物利用度与双头纳米系统提供的配体密度成正比。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fd/6472980/76061819f103/nihms-1018205-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fd/6472980/40cc69c51a19/nihms-1018205-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fd/6472980/3c23d0116478/nihms-1018205-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fd/6472980/64205240c493/nihms-1018205-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fd/6472980/76061819f103/nihms-1018205-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fd/6472980/40cc69c51a19/nihms-1018205-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fd/6472980/3c23d0116478/nihms-1018205-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fd/6472980/64205240c493/nihms-1018205-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fd/6472980/76061819f103/nihms-1018205-f0005.jpg

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1
Double-headed nanosystems for oral drug delivery.双头纳米系统用于口服药物递送。
Chem Commun (Camb). 2019 Apr 18;55(33):4761-4764. doi: 10.1039/c8cc10021g.
2
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J Control Release. 2023 Jan;353:621-633. doi: 10.1016/j.jconrel.2022.12.012. Epub 2022 Dec 14.
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Oral Nanocurcumin Alone or in Combination with Insulin Alleviates STZ-Induced Diabetic Neuropathy in Rats.口服姜黄素纳米粒单独或联合胰岛素缓解链脲佐菌素诱导的糖尿病大鼠神经病变。
Mol Pharm. 2022 Dec 5;19(12):4612-4624. doi: 10.1021/acs.molpharmaceut.2c00465. Epub 2022 Sep 15.
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Nanoparticles that do not compete with endogenous ligands - Molecular characterization in vitro, acute safety in canine, and interspecies pharmacokinetics modeling to humans.

本文引用的文献

1
Noncompetitive Active Transport Exploiting Intestinal Transferrin Receptors for Oral Delivery of Proteins by Tunable Nanoplatform.利用肠道转铁蛋白受体通过可调纳米平台进行蛋白质口服递送的非竞争性主动运输
ACS Macro Lett. 2017 Feb 21;6(2):161-164. doi: 10.1021/acsmacrolett.7b00035. Epub 2017 Feb 3.
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Advances in Biomaterials for Drug Delivery.药物递送生物材料的进展
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Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy.用于HIV抗逆转录病毒疗法的口服每周一次给药系统的研发。
不与内源性配体竞争的纳米颗粒 - 体外分子特征描述、犬类的急性安全性以及种间药代动力学模型到人体。
J Control Release. 2021 Apr 10;332:64-73. doi: 10.1016/j.jconrel.2021.02.009. Epub 2021 Feb 16.
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Systemic anti-inflammatory therapy aided by double-headed nanoparticles in a canine model of acute intraocular inflammation.在犬急性眼内炎模型中，双头纳米粒子辅助的全身抗炎治疗。
Sci Adv. 2020 Aug 26;6(35):eabb7878. doi: 10.1126/sciadv.abb7878. eCollection 2020 Aug.
5
Next-Generation Noncompetitive Nanosystems Based on Gambogic Acid: Identification of Transferrin Receptor Binding Sites, Regulatory Shelf Stability, and Their Preliminary Safety in Healthy Rodents.基于藤黄酸的下一代非竞争性纳米系统：转铁蛋白受体结合位点的鉴定、调节货架稳定性及其在健康啮齿动物中的初步安全性
ACS Appl Bio Mater. 2019 Aug 19;2(8):3540-3550. doi: 10.1021/acsabm.9b00419. Epub 2019 Jul 4.
6
Oral Drug Delivery Technologies-A Decade of Developments.口服药物递送技术：十年发展历程。
J Pharmacol Exp Ther. 2019 Sep;370(3):529-543. doi: 10.1124/jpet.118.255828. Epub 2019 Apr 22.
Nat Commun. 2018 Jan 9;9(1):2. doi: 10.1038/s41467-017-02294-6.
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Leveraging advances in biology to design biomaterials.利用生物学的进步来设计生物材料。
Nat Mater. 2017 Nov 24;16(12):1178-1185. doi: 10.1038/nmat4991.
5
Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics.对聚合物纳米颗粒上体内蛋白质冠形成的机制理解及其对药代动力学的影响。
Nat Commun. 2017 Oct 3;8(1):777. doi: 10.1038/s41467-017-00600-w.
6
Living Biomaterials.活生物材料。
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7
Drug delivery by supramolecular design.基于超分子设计的药物输送。
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Br J Pharmacol. 2017 Jul;174(13):2074-2084. doi: 10.1111/bph.13816. Epub 2017 May 30.
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Oral, ultra-long-lasting drug delivery: Application toward malaria elimination goals.口服、超长效药物输送：在消除疟疾目标方面的应用。
Sci Transl Med. 2016 Nov 16;8(365):365ra157. doi: 10.1126/scitranslmed.aag2374.
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The Next Generation Non-competitive Active Polyester Nanosystems for Transferrin Receptor-mediated Peroral Transport Utilizing Gambogic Acid as a Ligand.利用作为配体的藤黄酸构建用于转铁蛋白受体介导的口服递药的下一代非竞争型活性聚酯纳米系统。
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