双头纳米系统用于口服药物递送。
Double-headed nanosystems for oral drug delivery.
机构信息
Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, TAMU Mailstop 1114, College Station, Texas 77843, USA.
出版信息
Chem Commun (Camb). 2019 Apr 18;55(33):4761-4764. doi: 10.1039/c8cc10021g.
Abstract
We demonstrate a novel strategy to engineer double-headed nanosystems by chemical modification of the carboxyl terminal polyester with a linker that offers tripodal arrangement of ligands on the particle surfaces. The in vivo results suggest that the bioavailability of encapsulated curcumin is proportional to the ligand density rendered by double-headed nanosystems.
摘要
我们展示了一种通过化学修饰羧基末端聚酯的新策略来构建双头纳米系统，该策略使用一个连接子在颗粒表面提供三足配体排列。体内实验结果表明，包封姜黄素的生物利用度与双头纳米系统提供的配体密度成正比。
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