Rodriguez Kyle J, Gajewska Bernadetta, Pollard Jonas, Pellizzoni Michela M, Fodor Csaba, Bruns Nico
Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, 1700 Fribourg, Switzerland.
ACS Macro Lett. 2018 Sep 18;7(9):1111-1119. doi: 10.1021/acsmacrolett.8b00561. Epub 2018 Sep 4.
Reversible-deactivation radical polymerizations (controlled radical polymerizations) have revolutionized and revitalized the field of polymer synthesis. While enzymes and other biologically derived catalysts have long been known to initiate free radical polymerizations, the ability of peroxidases, hemoglobin, laccases, enzyme-mimetics, chlorophylls, heme, red blood cells, bacteria, and other biocatalysts to control or initiate reversible-deactivation radical polymerizations has only been described recently. Here, the scope of biocatalytic atom transfer radical polymerizations (bioATRP), enzyme-initiated reversible addition-fragmentation chain transfer radical polymerizations (bioRAFT), biocatalytic organometallic-mediated radical polymerizations (bioOMRP), and biocatalytic reversible complexation mediated polymerizations (bioRCMP) is critically reviewed, and the potential of these reactions for the environmentally friendly synthesis of precision polymers, for the preparation of functional nanostructures, for the modification of surfaces, and for biosensing is discussed.
可逆失活自由基聚合反应（可控自由基聚合反应）彻底改变并振兴了聚合物合成领域。虽然人们早就知道酶和其他生物衍生催化剂可引发自由基聚合反应，但过氧化物酶、血红蛋白、漆酶、酶模拟物、叶绿素、血红素、红细胞、细菌及其他生物催化剂控制或引发可逆失活自由基聚合反应的能力直到最近才被报道。本文对生物催化原子转移自由基聚合反应（bioATRP）、酶引发的可逆加成-断裂链转移自由基聚合反应（bioRAFT）、生物催化有机金属介导的自由基聚合反应（bioOMRP）以及生物催化可逆络合介导的聚合反应（bioRCMP）的范围进行了批判性综述，并讨论了这些反应在环境友好型精密聚合物合成、功能纳米结构制备、表面改性及生物传感方面的潜力。
