复发性转移性绒癌对依托泊苷和顺铂敏感，并用依托泊苷、甲氨蝶呤和放线菌素 D 治疗：病例报告。
Recurrent Metastatic Choriocarcinoma Responsive to Etoposide and Cisplatin with Etoposide, Methotrexate, and Dactinomycin: A Case Report.
机构信息
Department of General Practice and Emergency Medicine, Patan Academy of Health Sciences, Lagankhel, Lalitpur, Nepal.
Department of Oncology, Patan Academy of Health Sciences, Lagankhel, Lalitpur, Nepal.
出版信息
JNMA J Nepal Med Assoc. 2022 May 5;60(249):488-490. doi: 10.31729/jnma.7081.
UNLABELLED
Choriocarcinoma is a malignant trophoblastic tumour usually of placental origin. It is characterized by early metastasis to the brain and lungs. With early detection, it has a better prognosis with treatment. We report a case of 18 years female at 26 weeks of gestation in her third pregnancy who had a history of treatment for metastatic gestational trophoblastic neoplasm with chemotherapy and radiotherapy two years back. Therefore, she was managed as a case of recurrent choriocarcinoma with brain metastasis with chemotherapy (etoposide and cisplatin with etoposide, methotrexate, and dactinomycin) and was responsive. Her symptoms resolved and β-human chorionic gonadotropin dropped to normal value (<2.39 mIU/ml) which has shown that timely diagnosis and management can be vital for the successful treatment of brain metastasis.
KEYWORDS
chemotherapy; choriocarcinoma; metastasis; recurrence.
未注明
绒癌是一种源自胎盘的恶性滋养细胞肿瘤。其特征是早期转移至脑和肺。若早期发现，经治疗后预后较好。我们报告了一例 18 岁女性，第三次妊娠 26 周，两年前曾因转移性妊娠滋养细胞肿瘤接受化疗和放疗治疗。因此，她被诊断为复发性绒癌伴脑转移，采用化疗（依托泊苷和顺铂联合依托泊苷、甲氨蝶呤和多柔比星）治疗，效果良好。她的症状缓解，β-人绒毛膜促性腺激素降至正常水平（<2.39 mIU/ml），这表明及时诊断和治疗对于脑转移的成功治疗至关重要。
关键词
化疗；绒癌；转移；复发。
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