Department of Clinical Pharmacology, Maharajgunj Medical Campus, Institute of Medicine, Maharajgunj, Kathmandu, Nepal.
Manmohan Cardiothoracic Vascular and Transplant Center, Maharajgunj, Kathmandu, Nepal.
JNMA J Nepal Med Assoc. 2022 Mar 11;60(247):263-267. doi: 10.31729/jnma.7137.
Drug interactions are one of the major contributors to increase hospital stay, inflate health care expenses, and cause serious adverse events and end-organ damage. Patients admitted to the intensive care unit are already critically sick and are at greater risk of these adverse outcomes. The study aimed to find out the prevalence of potential drug-drug interactions in the Intensive Care Units of a tertiary care centre.
A descriptive cross-sectional study was conducted among the patients admitted in the Intensive Care Unit of a tertiary care hospital from April-June 2019. Ethical approval was taken from the Institutional Review Board at the institute (Reference number: 399). Convenience sampling method was used. Data was collected using proforma and potential drug-drug interactions were identified using Lexicomp® drug-interactions version 1.1 (Wolters Kluwer). All the drug interactions identified were classified and the severity scale of interactions was also defined. Statistical Package for the Social Sciences version 17.0 was used for data analysis. Point estimate at 95% Confidence Interval was calculated along with frequency, percentage, mean, standard deviation, and mode.
Out of 101 patients, the prevalence of the drug-drug interaction was found to be 90 (89.11%) (83.04-95.18 at 95% Confidence Interval). A total of 490 drug-drug interactions were identified. In severity scale, it was seen that 311 (63.46%) were of moderate severity and 303 (61.83%) of drug interactions were categorised as category C in risk rating.
Prevalence of potential drug-drug interactions was higher compared to similar published literature. The most common drug with potential interaction was fentanyl and among pairs was fentanyl plus paracetamol.
drug interactions; intensive care units; Nepal; software.
药物相互作用是导致住院时间延长、医疗费用增加以及严重不良事件和终末器官损伤的主要原因之一。入住重症监护病房的患者已经病情危急，发生这些不良后果的风险更高。本研究旨在了解三级保健中心重症监护病房潜在药物相互作用的发生率。
2019 年 4 月至 6 月，在一家三级医院的重症监护病房进行了一项描述性横断面研究。该研究获得了机构审查委员会的伦理批准（参考编号：399）。采用便利抽样法。使用表格收集数据，并使用 Lexicomp®药物相互作用版本 1.1（Wolters Kluwer）识别潜在的药物-药物相互作用。所有识别出的药物相互作用都进行了分类，并定义了相互作用的严重程度分级。使用社会科学统计软件包版本 17.0 进行数据分析。计算了 95%置信区间的点估计值以及频率、百分比、平均值、标准差和模式。
在 101 名患者中，发现药物-药物相互作用的发生率为 90 例（89.11%）（95%置信区间为 83.04-95.18）。共发现 490 种药物-药物相互作用。在严重程度分级中，311 种（63.46%）为中度严重，303 种（61.83%）药物相互作用被归类为风险分级的 C 类。
与类似的已发表文献相比，潜在药物相互作用的发生率较高。最常见的潜在相互作用药物是芬太尼，而在药物对中，芬太尼加扑热息痛最为常见。
药物相互作用；重症监护病房；尼泊尔；软件。
