Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal.
Jibjibe Rural Hospital, Jibjibe, Rasuwa, Nepal.
JNMA J Nepal Med Assoc. 2022 Sep 1;60(253):766-769. doi: 10.31729/jnma.7823.
Organophosphates are potent cholinesterase inhibitors that when ingested in excessive amounts can be fatal. Organophosphorus poisoning has become an important clinical problem with increased mortality in the country from accidental or intentional ingestion of, or exposure to the pesticide. This study aimed to find out the prevalence of organophosphorus poisoning among patients admitted to the Intensive Care Unit of the Department of Internal Medicine in a tertiary care centre.
A descriptive cross-sectional study was conducted among patients admitted to the Intensive Care Unit of the Department of Internal Medicine of a tertiary care centre after receiving ethical approval from the Institutional Review Committee (Reference number: 2003202205). The study was conducted between 1 February 2021 and 1 February 2022 using hospital records. Convenience sampling was done among the patients who met the eligibility criteria. The diagnosis of organophosphorus poisoning was made based on the patient's history, clinical examination and the measurement of serum acetylcholinesterase levels. Point estimate and 95% Confidence Interval were calculated.
Among 1108 patients admitted, organophosphorus poisoning was seen in 50 (4.15%) (3.29-5.73, 95% Confidence Interval).
Our study found that the prevalence of organophosphorus poisoning was lower when compared to similar studies done in similar settings.
有机磷化合物是强效的胆碱酯酶抑制剂，摄入过量时可能致命。有机磷中毒已成为一个重要的临床问题，该国因意外或故意摄入、接触农药而导致的死亡率有所上升。本研究旨在了解在一家三级护理中心的内科重症监护病房住院的患者中有机磷中毒的流行情况。
本研究是一项描述性的横断面研究，在获得机构审查委员会的伦理批准（参考编号：2003202205）后，在一家三级护理中心的内科重症监护病房对患者进行。该研究于 2021 年 2 月 1 日至 2022 年 2 月 1 日期间使用医院记录进行。采用便利抽样法对符合入选标准的患者进行抽样。根据患者的病史、临床检查和血清乙酰胆碱酯酶水平的测量来诊断有机磷中毒。计算点估计值和 95%置信区间。
在 1108 名入院患者中，有 50 名（4.15%）（3.29-5.73，95%置信区间）患有有机磷中毒。
与在类似环境中进行的类似研究相比，我们的研究发现有机磷中毒的患病率较低。
