Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
Front Immunol. 2022 May 13;13:855795. doi: 10.3389/fimmu.2022.855795. eCollection 2022.
Eryptosis is a programmed cell death-like process that occurs in red blood cells. Although the red blood cells are anucleated, there are similarities between eryptosis and apoptosis, such as increased calcium efflux, calpain activation, phosphatidylserine exposure, cell blebbing and cell shrinkage. Eryptosis occurs physiologically in red blood cells, as a consequence of the natural senescence process of these cells, but it can also be stimulated in pathological situations such as metabolic syndromes, uremic syndromes, polycythemia vera, anemias such as sickle cell anemia and thalassemia, and infectious processes including infection. Infection-induced eryptosis is believed to contribute to damage caused by , but it's still a topic of debate in the literature. In this review, we provided an overview of eryptosis mechanisms and its possible pathogenic role in malaria.
细胞凋亡样红细胞程序性死亡即细胞发生细胞凋亡样的红细胞程序性死亡。尽管红细胞无核，但细胞发生细胞凋亡样的红细胞程序性死亡与细胞凋亡之间存在诸多相似性，例如钙外流增加、钙蛋白酶激活、磷脂酰丝氨酸暴露、细胞起泡和细胞皱缩。生理性红细胞发生细胞凋亡样的红细胞程序性死亡是这些细胞自然衰老过程的结果，但在代谢综合征、尿毒症综合征、真性红细胞增多症、镰状细胞贫血和地中海贫血等病理情况下，也可刺激发生细胞发生细胞凋亡样的红细胞程序性死亡，感染过程包括 感染也可刺激发生细胞发生细胞凋亡样的红细胞程序性死亡。认为 感染诱导的细胞发生细胞凋亡样的红细胞程序性死亡可导致疟原虫引起的损伤，但这在文献中仍然存在争议。在本文综述中，我们对细胞发生细胞凋亡样的红细胞程序性死亡的机制及其在疟疾中的可能致病作用进行了概述。
