State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Environ Res. 2020 May;184:109382. doi: 10.1016/j.envres.2020.109382. Epub 2020 Mar 17.
Animal experiments suggest that bisphenol A (BPA) could potentially induce lipid abnormalities. However, whether BPA exposure associates with altered lipid metabolism in humans has not been fully elucidated. We thus comprehensively investigated the relationship of BPA exposure and its change with lipid profile and development of incident dyslipidemia among Chinese adults. We initially included 1872 participants aged 40 years or older who were free of dyslipidemia at baseline in 2009, and followed them for 4 years. Urinary BPA and serum lipids including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) were determined at baseline and follow-up. Linear mixed models were used for repeated measures analyses and linear and logistic regression models were used to evaluate longitudinal changes in lipid profile and risk of incident dyslipidemia. In repeated measures analyses, per doubling of urinary BPA concentrations was associated with higher serum levels of LDL-C, non-HDL-C, TC to HDL-C ratio, and lower levels of HDL-C and TG. In longitudinal change analyses, participants with high BPA at both baseline and follow-up showed an additional 2.94% increase in LDL-C (95% CI: 0.02%, 5.95%) and 6.12% increase in TG (95% CI: 0.74%, 11.8%), as compared with those who maintained low BPA. Furthermore, participants with sustained high BPA at two time points had increased odds of developing hyper-LDL cholesterolemia (odds ratio = 1.93, 95% CI: 1.02, 3.66). Our results suggested that high BPA exposure, especially maintained a long time period apart, was associated with deterioration of lipid profiles among middle-aged and elderly adults, supporting a detrimental role of BPA in lipid metabolism.
动物实验表明，双酚 A（BPA）可能潜在地诱导脂质异常。然而，BPA 暴露是否与人类脂质代谢的改变有关尚未完全阐明。因此，我们全面研究了 BPA 暴露及其变化与中国成年人脂质谱和新发血脂异常之间的关系。我们最初纳入了 1872 名年龄在 40 岁或以上且在 2009 年基线时无血脂异常的参与者，并随访了 4 年。在基线和随访时测定了尿液 BPA 和血清脂质，包括总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和甘油三酯（TG）。使用线性混合模型进行重复测量分析，以及线性和逻辑回归模型评估脂质谱的纵向变化和新发血脂异常的风险。在重复测量分析中，尿液 BPA 浓度每增加一倍与血清 LDL-C、非高密度脂蛋白胆固醇、TC/HDL-C 比值升高以及 HDL-C 和 TG 水平降低有关。在纵向变化分析中，与基线和随访时均保持低 BPA 的参与者相比，基线和随访时 BPA 水平高的参与者 LDL-C 增加 2.94%（95%CI：0.02%，5.95%），TG 增加 6.12%（95%CI：0.74%，11.8%）。此外，在两个时间点持续高 BPA 的参与者发生高 LDL 胆固醇血症的几率增加（比值比=1.93，95%CI：1.02，3.66）。我们的研究结果表明，高 BPA 暴露，特别是长期暴露，与中老年人群脂质谱的恶化有关，支持 BPA 在脂质代谢中的有害作用。
