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[慢性细菌感染中的肾小球肾炎]

[Glomerulonephritis in chronic bacterial infections].

作者信息

Probst W, Blumberg A

出版信息

Schweiz Med Wochenschr. 1987 Feb 21;117(8):265-9.

PMID:3563451
Abstract

Five patients with chronic bacterial infections (two with osteomyelitis, two with infected vascular prostheses, one with soft tissue abscess), but without endocarditis, developed signs of glomerulonephritis and renal failure. Histological examination in three revealed mainly proliferative glomerular alterations. The outcome of glomerulonephritis paralleled the course of infection. Recovery or marked improvement occurred in three patients in whom the infection was cured, one case with smoldering infection eventually developed endstage renal failure, and one with persistent infection died from severe complications with acute renal failure. If renal failure occurs in the setting of suppurative infection, so-called infection-associated glomerulonephritis must be considered. Prompt and effective eradication of infection has an important bearing on the course of renal function.

摘要

五名患有慢性细菌感染(两名患有骨髓炎,两名患有感染性血管假体,一名患有软组织脓肿)但无心内膜炎的患者出现了肾小球肾炎和肾衰竭的症状。三名患者的组织学检查主要显示肾小球增生性改变。肾小球肾炎的转归与感染病程平行。三名感染得到治愈的患者康复或显著改善,一名感染持续存在的患者最终发展为终末期肾衰竭,一名持续感染的患者死于严重并发症伴急性肾衰竭。如果在化脓性感染的情况下发生肾衰竭,则必须考虑所谓的感染相关性肾小球肾炎。及时有效地根除感染对肾功能的病程具有重要影响。

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