Chaudhari Ramesh, Patel Vishva, Kumar Ashutosh
Biological & Life Sciences, School of Arts & Sciences, Ahmedabad University Central Campus, Navrangpura Ahmedabad 380009 Gujarat India
Nanoscale Adv. 2024 Apr 10;6(9):2270-2286. doi: 10.1039/d4na00086b. eCollection 2024 Apr 30.
Breast cancer is a global health challenge with staggering statistics underscoring its pervasive impact. The burden of this disease is measured in terms of its prevalence and the challenges it poses to healthcare systems, necessitating a closer look at its epidemiology and impact. Current breast cancer treatments, including surgery, chemotherapy, radiation therapy, and targeted therapies, have made significant strides in improving patient outcomes. However, they are not without limitations, often leading to adverse effects and the development of drug resistance. This comprehensive review delves into the complex landscape of breast cancer, including its incidence, current treatment modalities, and the inherent limitations of existing therapeutic approaches. It also sheds light on the promising role of nanotechnology, encompassing both inorganic and organic nanoparticles equipped with the ability to selectively deliver therapeutic agents to tumor sites, in the battle against breast cancer. The review also addresses the emerging therapies, their associated challenges, and the future prospects of targeted drug delivery in breast cancer management.
乳腺癌是一项全球性的健康挑战，其惊人的数据凸显了它广泛的影响。这种疾病的负担通过其患病率以及它给医疗系统带来的挑战来衡量，这就需要更深入地研究其流行病学和影响。目前的乳腺癌治疗方法，包括手术、化疗、放射治疗和靶向治疗，在改善患者预后方面已经取得了显著进展。然而，它们并非没有局限性，常常会导致不良反应和耐药性的产生。这篇综述深入探讨了乳腺癌的复杂情况，包括其发病率、当前的治疗方式以及现有治疗方法固有的局限性。它还揭示了纳米技术在对抗乳腺癌中的前景广阔的作用，纳米技术包括无机和有机纳米颗粒，这些纳米颗粒能够选择性地将治疗剂输送到肿瘤部位。该综述还讨论了新兴疗法、它们相关的挑战以及乳腺癌治疗中靶向给药的未来前景。
