College of Materials Science & Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
Department of Chemical, Biomolecular, and Corrosion Engineering, The University of Akron, Akron, Ohio 44325, United States.
ACS Appl Mater Interfaces. 2021 Jan 20;13(2):3089-3097. doi: 10.1021/acsami.0c16510. Epub 2021 Jan 5.
Numerous efforts to fabricate antimicrobial surfaces by simple yet universal protocols with high efficiency have attracted considerable interest but proved to be particularly challenging. Herein, we designed and fabricated a series of antimicrobial polymeric coatings with different functions from single to multiple mechanisms by selectively utilizing diethylene glycol diglycidyl ether (PEGDGE), polylysine, and poly[glycidylmethacrylate--3-(dimethyl(4-vinylbenzyl)ammonium)propyl sulfonate] (poly(GMA--DVBAPS)) via straightforward mussel-inspired codeposition techniques. Bactericidal polylysine endowed the modified surfaces with a high ability (∼90%) to kill attached bacteria, while PEGDGE components with unique surface hydration prevented bacterial adhesion, avoiding the initial biofilm formation. Moreover, excellent salt-responsive poly(GMA--DVBAPS) enabled reactant polymeric coatings to change chain conformations from shrinkable to stretchable state and subsequently release >90% attached bacteria when treated with NaCl solution, even after repeated cycles. Therefore, the obtained polymeric coatings, polydopamine/poly(GMA--DVBAPS) (PDA/PDV), polydopamine/polylysine/poly(GMA--DVBAPS) (PDA/l-PDV), and polydopamine/polylysine/poly(GMA--DVBAPS)/diethylene glycol diglycidyl ether (PDA/l-PDV-PEGDGE), controllably realized functions from single and dual to multiple antimicrobial mechanisms, as evidenced by long-term antifouling activity to bacteria, high bactericidal efficiency, and salt-responsive bacterial regeneration performance with several bacterial killing-release cycles. This study not only contributes to mussel-inspired chemistry for polymeric coatings with controllable functions but also provides a series of reliable and highly efficient antimicrobial surfaces for potential biomedical applications.
通过简单而通用的高效方法制造抗菌表面的大量努力引起了相当大的兴趣，但事实证明这特别具有挑战性。在此，我们通过选择性地利用二甘醇二缩水甘油醚（PEGDGE）、聚赖氨酸和聚[甲基丙烯酸缩水甘油酯-3-（二甲基（4-乙烯基苄基）铵基）丙磺酸]（poly（GMA-DVBAPS）），通过简单的贻贝启发共沉积技术设计并制造了一系列具有不同功能的抗菌聚合物涂层，从单一机制到多种机制。杀菌聚赖氨酸使改性表面具有很高的能力（约 90%）杀死附着的细菌，而具有独特表面水合作用的 PEGDGE 成分阻止了细菌的附着，避免了初始生物膜的形成。此外，优异的盐响应性 poly（GMA-DVBAPS）使反应物聚合物涂层能够从可收缩状态转变为可拉伸状态，当用 NaCl 溶液处理时，随后释放超过 90%的附着细菌，即使经过多次循环也是如此。因此，所获得的聚合物涂层，聚多巴胺/聚（GMA-DVBAPS）（PDA/PDV）、聚多巴胺/聚赖氨酸/聚（GMA-DVBAPS）（PDA/l-PDV）和聚多巴胺/聚赖氨酸/聚（GMA-DVBAPS）/二甘醇二缩水甘油醚（PDA/l-PDV-PEGDGE），从单一和双重到多种抗菌机制，可控地实现了功能，如对细菌的长期抗污活性、高杀菌效率和盐响应性细菌再生性能，具有几个细菌杀伤-释放循环。这项研究不仅为具有可控功能的聚合物涂层的贻贝启发化学做出了贡献，还为潜在的生物医学应用提供了一系列可靠且高效的抗菌表面。
