Department of Biotechnology, Institute of Graduate studies and Research, Alexandria University, Alexandria, 21526, Egypt.
J Control Release. 2022 Aug;348:57-83. doi: 10.1016/j.jconrel.2022.05.037. Epub 2022 Jun 2.
Nanoparticles-in-nanofibers composites comprise an attractive approach for controlling release and delivery of many active molecules for versatile biomedical applications. Incorporation of drug-loaded nanoparticles within these composites can afford the encapsulation of one or more drug with sequential drug release, which can be tuned according to the assigned function. Moreover, existence of nanoparticles within the nanofibrous matrix was found to favor the morphological and mechanical properties of the developed composites. In this review, the latest biomedical advances for nanoparticles-in-nanofibers composites will be highlighted including; tissue regeneration, antimicrobial applications, wound healing, cancer management, cardiovascular disorders, ophthalmic applications, vaginal drug delivery, biosensors and biomedical filters. These composites incorporating multiple types of nanoparticles could be very promising drug delivery platforms.
纳米粒子-纳米纤维复合材料是一种很有吸引力的方法，可用于控制许多活性分子的释放和输送，从而实现多种生物医学应用。将载药纳米粒子掺入这些复合材料中，可以实现一种或多种药物的封装，并实现顺序药物释放，这可以根据指定的功能进行调整。此外，发现在纳米纤维基质中存在纳米粒子有利于所开发复合材料的形态和机械性能。在这篇综述中，将重点介绍纳米粒子-纳米纤维复合材料在组织再生、抗菌应用、伤口愈合、癌症管理、心血管疾病、眼科应用、阴道药物输送、生物传感器和生物医学过滤等生物医学领域的最新进展。这些包含多种类型纳米粒子的复合材料可能是非常有前途的药物输送平台。
