Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília , Brasília, Brazil.
Programa de Pós-Graduação em Ciências da Saúde, Universidade de Brasília , Brasília, Brazil.
Expert Opin Drug Deliv. 2020 Jul;17(7):919-930. doi: 10.1080/17425247.2020.1762564. Epub 2020 May 13.
Due to the complexity of different oral infections, new anti-infective nanotechnological approaches have been emerging for dentistry in recent years. These strategies may contribute to antimicrobial molecules delivery, tissue regeneration, and oral health maintenance by acting in a more specific site and not being cytotoxic. In this context, nanofibers appear as versatile structures and might act both in the release of antimicrobial molecules and as a scaffold for new tissue formation.
This review addresses the application of different nanofibers as new strategies for the delivery of antimicrobial molecules for dentistry. Here, we present the main polymers used to construct nanofibers, methods of production and mainly their antimicrobial activity against microorganisms commonly responsible for the usual dental infections. These biomaterials may be associated to restorative materials, prostheses, and mucoadhesive structures. Besides, nanofibers can be used for endodontic or periodontal therapy, or even on implant surfaces.
A wide variety of studies report the potential application of anti-infective nanofibers in the oral cavity. Although there are still several barriers between and studies, these new formulations appear as promising new therapies for dentistry.
由于不同口腔感染的复杂性，近年来，新的抗感染纳米技术方法在牙科领域不断涌现。这些策略可以通过在更特定的部位发挥作用而不具有细胞毒性，从而有助于抗菌分子的输送、组织再生和口腔健康的维持。在这种情况下，纳米纤维作为多功能结构出现，并且可以在释放抗菌分子和作为新组织形成的支架方面发挥作用。
本文综述了不同纳米纤维在牙科抗菌分子传递方面的新策略的应用。在这里，我们介绍了用于构建纳米纤维的主要聚合物、生产方法，以及它们对抗常见引起常见牙科感染的微生物的抗菌活性。这些生物材料可以与修复材料、假体和粘膜附着结构相关联。此外，纳米纤维可用于牙髓或牙周治疗，甚至可用于植入物表面。
大量研究报告了抗感染纳米纤维在口腔中的潜在应用。尽管在研究之间仍然存在许多障碍，但这些新配方似乎为牙科提供了有前途的新疗法。
