Department of Human Physiology, University of Oregon, USA.
Department of Human Physiology, University of Oregon, USA; Institute for Neuroscience, University of Texas at Austin, USA.
Neuropsychologia. 2022 Jul 29;172:108276. doi: 10.1016/j.neuropsychologia.2022.108276. Epub 2022 May 27.
It is well established that the amplitude of beta oscillations (∼13-30 Hz)-recorded over the sensorimotor cortex-distinctly change throughout movement. Specifically, a movement-related beta decrease (MRBD) occurs before and during movement, and a post-movement beta rebound (PMBR) follows. We investigated how the magnitude of the MRBD and PMBR vary when participants are put in an experimentally induced slow versus fast movement state. Individuals performed a task with blocks that elicited longer reaction times (RTs) and shorter RTs (SLOW and FAST blocks, respectively) while scalp-electroencephalography (EEG) was recorded. The timing of an upcoming movement was also modulated to create blocks with certain and uncertain response timing (FIXED and VARIED blocks, respectively). We found that beta modulation was reduced in SLOW blocks compared to FAST blocks (i.e., a less negative MRBD and less positive PMBR). For the movement certainty manipulation, we saw mixed behavioral and EEG results. Our primary finding of reduced beta modulation during an experimentally induced "slowed movement state" aligns with previous work showing reduced movement-related beta activity in patients with Parkinson's disease.
已经证实，记录在感觉运动皮层上的β振荡幅度（约 13-30 Hz）在运动过程中会发生明显变化。具体来说，在运动前和运动期间会出现与运动相关的β波减少（MRBD），之后会出现运动后β波反弹（PMBR）。我们研究了当参与者处于实验诱导的慢运动和快运动状态时，MRBD 和 PMBR 的幅度如何变化。个体在头皮脑电图（EEG）记录的同时执行具有较长反应时间（RT）和较短 RT 的块（分别为 SLOW 和 FAST 块）。还对即将进行的运动的时间进行了调制，以创建具有确定和不确定响应时间的块（分别为 FIXED 和 VARIED 块）。我们发现，与 FAST 块相比，SLOW 块中的β调制减少（即，MRBD 不那么负，PMBR 不那么正）。对于运动确定性的操作，我们看到了混合的行为和脑电图结果。我们在实验诱导的“慢运动状态”期间β调制减少的主要发现与先前的研究结果一致，即帕金森病患者的运动相关β活动减少。
