Impact of Lysosomal Fraction on Melanin Synthesis Inhibition in a Zebrafish Melanogenesis Phenotype Model.

To develop whitening cosmetic materials, we conducted a study on lysosomes that decisively contribute to the decomposition of melanin during autophagy in keratinocytes. In this study, we found that the lysosomal fraction inhibits melanin synthesis in melanocyte, and the potential for the whitening function of lysosomal fraction to degrade melanin in the cells, or accompany other melanin synthesis inhibition pathways, including tyrosinase inhibition. Additionally, through the zebrafish test, we confirmed the effect of lysosomal fraction on melanin production in vivo. The results suggest that the lysosome fraction effectively reduces melanin or inhibits melanogenesis in a melanogenesis phenotype whole-animal model.