Graduate School of Semiconductor and Chemical Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54896, Republic of Korea.
School of Biological Science, Chungbuk National University, Chungdae-ro 1, Seowon-Gu, Cheongju, Chungbuk, 28644, Republic of Korea.
Mol Biotechnol. 2022 Dec;64(12):1350-1355. doi: 10.1007/s12033-022-00516-x. Epub 2022 May 30.
To develop whitening cosmetic materials, we conducted a study on lysosomes that decisively contribute to the decomposition of melanin during autophagy in keratinocytes. In this study, we found that the lysosomal fraction inhibits melanin synthesis in melanocyte, and the potential for the whitening function of lysosomal fraction to degrade melanin in the cells, or accompany other melanin synthesis inhibition pathways, including tyrosinase inhibition. Additionally, through the zebrafish test, we confirmed the effect of lysosomal fraction on melanin production in vivo. The results suggest that the lysosome fraction effectively reduces melanin or inhibits melanogenesis in a melanogenesis phenotype whole-animal model.
为了开发美白化妆品材料，我们对角质细胞自噬过程中决定黑色素分解的溶酶体进行了研究。在这项研究中，我们发现溶酶体部分抑制黑素细胞中的黑色素合成，溶酶体部分降解细胞内黑色素的美白功能潜力，或伴随其他黑色素合成抑制途径，包括抑制酪氨酸酶。此外，通过斑马鱼试验，我们证实了溶酶体部分对体内黑色素生成的影响。结果表明，溶酶体部分在黑色素生成表型的整体动物模型中有效减少黑色素或抑制黑色素生成。
