儿童期铅暴露对智商测试分数的影响：病例对照研究的系统评价和荟萃分析。
The effect of lead exposure on IQ test scores in children under 12 years: a systematic review and meta-analysis of case-control studies.
机构信息
Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
出版信息
Syst Rev. 2022 May 30;11(1):106. doi: 10.1186/s13643-022-01963-y.
An inevitable exposure to the toxic heavy metal such as lead in our environmental can have irreversible effects on children's mental performance.In this study, 3316 children in 8 case-control studies were selected for review. The case group was exposed to a concentration of lead above 10 μg/dL, and the control group was exposed to a concentration of less than 10 μg/dL, but the duration of exposure was different among studies, and the subgroup analysis was performed based on this variable.In the subgroup with duration of exposure less than the average of 4.5 years, the difference of IQ test score between two groups was significant (MD = -3.53) (P-value <0.05). Also, in the subgroup with more than 4.5 years of duration, the difference of IQ test score was significant (MD = -22.63) (P-value < 0.001).This study demonstrates that the concentration and duration of lead exposure have a large effect on mental function in children.
在我们的环境中不可避免地接触到有毒重金属，如铅，可能会对儿童的精神表现产生不可逆转的影响。在这项研究中，选择了 8 项病例对照研究中的 3316 名儿童进行回顾。病例组暴露于浓度超过 10μg/dL 的铅，对照组暴露于浓度低于 10μg/dL 的铅，但研究中的暴露持续时间不同，根据该变量进行了亚组分析。在暴露持续时间短于平均 4.5 年的亚组中，两组之间的智商测试得分差异显著 (MD = -3.53) (P 值 <0.05)。此外，在暴露持续时间超过 4.5 年的亚组中，智商测试得分的差异也很显著 (MD = -22.63) (P 值 < 0.001)。这项研究表明，铅暴露的浓度和持续时间对儿童的精神功能有很大影响。
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