Payne K A, Murray W B, Barrett H
S Afr Med J. 1987 Mar 21;71(6):359-61.
The postoperative analgesic efficacy of buprenorphine (Temgesic; R & C Pharmaceuticals) 0.004 mg/kg and morphine 0.15 mg/kg were compared in 60 patients, both agents given by intramuscular injection. According to patients, buprenorphine gave better analgesia. There was no difference in the number of analgesic injections the two groups received in the 24-hour postoperative period. Cardiovascular and respiratory systems were not depressed by either drug. Side-effects were not marked, nausea being the most common in both groups. Morphine had a greater effect on the mood of patients. Buprenorphine proved a satisfactory analgesic for postoperative use by intramuscular injection.
对60例患者比较了肌内注射0.004毫克/千克丁丙诺啡（替利定；R&C制药公司）和0.15毫克/千克吗啡的术后镇痛效果。据患者反映，丁丙诺啡的镇痛效果更好。两组患者在术后24小时内接受的镇痛注射次数没有差异。两种药物对心血管和呼吸系统均无抑制作用。副作用不明显，恶心是两组中最常见的。吗啡对患者情绪的影响更大。事实证明，丁丙诺啡是一种令人满意的术后肌内注射用镇痛药。
