Dingus D J, Sherman J C, Rogers D A, DiPiro J T, May R, Bowden T A
Department of Surgery, Medical College of Georgia, Augusta.
Surg Gynecol Obstet. 1993 Jul;177(1):1-6.
Buprenorphine is an opioid agonist-antagonist that has emerged as an option for postoperative analgesia. We compared the postoperative hospital course of patients undergoing open cholecystectomy who received buprenorphine hydrochloride with those who received morphine sulfate. Patients in both groups administered the analgesic using a patient-controlled analgesia infusion device. Comparison of the two groups demonstrated no difference with respect to clinical indicators of intestinal motility, visual analog pain scores and hospitalization period. Postoperative nausea occurred more frequently in the buprenorphine group, but the difference was not significant. We concluded that the patient-controlled analgesia device is a valuable tool for comparing different analgesics. Both analgesics tested provide adequate analgesia with a similar postoperative course.
丁丙诺啡是一种阿片类激动-拮抗剂，已成为术后镇痛的一种选择。我们比较了接受盐酸丁丙诺啡的开腹胆囊切除术患者与接受硫酸吗啡的患者的术后住院过程。两组患者均使用患者自控镇痛输注装置给药。两组比较显示，在肠蠕动的临床指标、视觉模拟疼痛评分和住院时间方面无差异。丁丙诺啡组术后恶心的发生率更高，但差异不显著。我们得出结论，患者自控镇痛装置是比较不同镇痛药的一种有价值的工具。所测试的两种镇痛药均能提供充分的镇痛效果，且术后过程相似。
