Ogura Yasuhiro, Koyama Teruhide, Ozaki Etsuko, Omichi Chie, Uehara Ritei
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Department of Psychiatry, Shiga University of Medical Science, Shiga 520-2192, Japan.
Prev Med Rep. 2022 May 23;28:101844. doi: 10.1016/j.pmedr.2022.101844. eCollection 2022 Aug.
Several studies have been reported that sleep duration and circadian rhythms are associated with metabolic syndrome (MetS). However, there are few studies of a relationship between sleep and MetS based on subjective evaluation of sleep regularity. The aim of this study is to examine the relationship between subjective sleep irregularity and metabolic syndrome. This cross-sectional study included 3,880 participants (1,383 males, 2,497 females) from 2013 to 2017, and we use a self-administered questionnaire to acquire information about sleep (sleep regularity, duration and bedtime). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression analyses to evaluate the associations between sleep regularity and the prevalence of MetS. The irregularity of sleep was significantly associated with MetS (OR 1.231, 95% CI 1.101-1.375) adjusted for age, sex, METs, sleep duration, bedtime, drinking and smoking statuses, and a history of using sleeping pills. We examined the interaction of MetS with sleep regularity and sleep duration/bedtime, stratified by multiplying the two groups of sleep regularity/irregularity and the three groups of sleep duration/bedtime. Each group of sleep duration/bedtime showed no relationship in the sleep regularity group with MetS, but a significant relationship in the sleep irregularity group. Leptin was significantly elevated in the irregular sleep group regardless of sleep duration and bedtime. Although many studies have shown a link between sleep and MetS especially in terms of sleep duration, this study showed that irregular sleep is more strongly associated with MetS than sleep duration or bedtime.
已有多项研究报道，睡眠时间和昼夜节律与代谢综合征（MetS）相关。然而，基于对睡眠规律性的主观评估来研究睡眠与MetS之间关系的研究却很少。本研究的目的是探讨主观睡眠不规律与代谢综合征之间的关系。这项横断面研究纳入了2013年至2017年间的3880名参与者（1383名男性，2497名女性），我们使用自填式问卷来获取有关睡眠的信息（睡眠规律性、时长和就寝时间）。使用逻辑回归分析计算比值比（OR）和95%置信区间（CI），以评估睡眠规律性与MetS患病率之间的关联。在对年龄、性别、代谢当量、睡眠时间、就寝时间、饮酒和吸烟状况以及使用安眠药史进行调整后，睡眠不规律与MetS显著相关（OR 1.231，95% CI 1.101 - 1.375）。我们通过将两组睡眠规律性/不规律性与三组睡眠时间/就寝时间相乘进行分层，研究了MetS与睡眠规律性和睡眠时间/就寝时间之间的相互作用。在睡眠规律组中，每组睡眠时间/就寝时间与MetS均无关系，但在睡眠不规律组中则存在显著关系。无论睡眠时间和就寝时间如何，瘦素在不规律睡眠组中均显著升高。尽管许多研究已表明睡眠与MetS之间存在关联，尤其是在睡眠时间方面，但本研究表明，不规律睡眠与MetS的关联比睡眠时间或就寝时间更强。
