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基于锰氧化物纳米酶掺杂的硅藻用于安全高效治疗种植体周围炎。

Manganese Oxide Nanozyme-Doped Diatom for Safe and Efficient Treatment of Peri-Implantitis.

机构信息

Department of Prosthodontics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 110-749, South Korea.

Department of Physiology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 110-749, South Korea.

出版信息

ACS Appl Mater Interfaces. 2022 Jun 22;14(24):27634-27650. doi: 10.1021/acsami.2c05166. Epub 2022 May 31.

Abstract

Peri-implantitis is a major cause of dental implant failure. Bacterial biofilm contamination on the implant induces surrounding bone resorption and soft tissue inflammation, leading to severe deterioration of oral health. However, conventional biofilm removal procedures, such as mechanical decontamination and antiseptic application, are not effective enough to induce reosseointegration on decontaminated implant surfaces. This is due to (1) incomplete decontamination of the biofilm from inaccessible areas and (2) physicochemical alteration of implant surfaces caused by decontamination procedures. Herein, a safe and effective therapeutic approach for peri-implantitis is developed, which involves decontamination of implant-bound biofilms using the kinetic energy of microsized oxygen bubbles generated from the catalytic reaction between hydrogen peroxide (HO) and manganese oxide (MnO) nanozyme sheet-doped silica diatom microparticles (Diatom Microbubbler, DM). Rapidly moving microsized DM particles are able to penetrate narrow spaces between implant screws, exerting just the right amount of force to entirely destroy biofilms without harming the surrounding mucosa or implant surfaces, as opposed to conventional antiseptics such as chlorhexidine or 3% HO when used alone. Consequently, decontamination with DM facilitates successful reosseointegration on the peri-implantitis-affected implant surface. In summary, our new DM-based therapeutic approach will become a promising alternative to resolve clinically challenging aspects of peri-implantitis.

摘要

种植体周围炎是导致种植牙失败的主要原因。种植体上细菌生物膜的污染会引起周围骨吸收和软组织炎症,导致口腔健康严重恶化。然而,传统的生物膜去除程序,如机械去污和防腐剂应用,不足以在去污的种植体表面诱导再矿化。这是由于(1)生物膜在无法到达的区域无法完全去除,(2)去污程序导致种植体表面的物理化学性质发生改变。在此,开发了一种安全有效的种植体周围炎治疗方法,该方法使用过氧化氢 (HO) 和氧化锰 (MnO) 纳米酶片掺杂二氧化硅硅藻微球 (Diatom Microbubbler, DM) 之间催化反应产生的微氧气泡的动能来去除种植体结合的生物膜。快速移动的微 DM 颗粒能够穿透种植体螺丝之间的狭窄空间,施加适量的力来完全破坏生物膜,而不会像单独使用洗必泰或 3% HO 等传统防腐剂那样伤害周围的粘膜或种植体表面。因此,DM 的去污作用有助于在受种植体周围炎影响的种植体表面成功再矿化。总之,我们的新 DM 治疗方法将成为解决种植体周围炎临床挑战方面的有前途的替代方法。

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