Department of Health and Safety Convergence Science, Korea University, Anam-ro 145, Seongbuk-gu, Seoul, 02841, South Korea; BK21 FOUR R & E Center for Learning Health System, Korea University, Anam-ro 145, Seongbuk-gu, Seoul, 02841, South Korea.
Institute of Health Sciences, Korea University, Anam-ro 145, Seongbuk-gu, Seoul 02841, South Korea.
Int J Hyg Environ Health. 2022 Jun;243:113988. doi: 10.1016/j.ijheh.2022.113988. Epub 2022 May 28.
Pyrethroid insecticides have been broadly used as pest control in agriculture and residential spaces, exerting high effectiveness of insecticidal property and relatively low toxicity to humans. Several animal studies suggested that exposure to pyrethroids may induce hematological abnormalities, thereby altering the number of blood cells and resulting in blood disorders. However, no epidemiologic study has reported on the effect of pyrethroid insecticide exposure on hematological changes, except for occupational exposure. This study aimed to investigate the effect of urinary 3-phenoxybenzoic acid (3-PBA) concentrations on hematological parameters in a representative South Korean adult population. We analyzed data from 6296 adults enrolled in the Korean National Environmental Health Survey (2012-2014). We employed multiple linear regression analysis to evaluate the association of urinary 3-PBA levels with eight hematological profiles: white blood cells (WBCs), red blood cells (RBCs), hemoglobin, hematocrit, platelets, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC). The urinary 3-PBA levels were negatively associated with WBC, RBC, and hemoglobin levels and positively associated with MCV levels. The direction and magnitude of the association between the 3-PBA and hematological parameters varied according to sex and age. The adverse effects of 3-PBA on hematological parameters were distinctive among males aged 60 years and older. In this age group, 3-PBA levels were negatively associated with the WBC, RBC, hemoglobin, hematocrit, and MCHC levels among males. This study is the first to verify that urinary 3-PBA concentrations at the levels found in a Korean population are associated with blood parameters. This finding merits further investigation to understand the impact of 3-PBA on human blood function and public health.
拟除虫菊酯杀虫剂已广泛用于农业和住宅空间的害虫防治，具有高效的杀虫性能和相对较低的人类毒性。一些动物研究表明，接触拟除虫菊酯可能会引起血液异常，从而改变血细胞数量并导致血液疾病。然而，除了职业接触外，没有流行病学研究报告过拟除虫菊酯杀虫剂暴露对血液变化的影响。本研究旨在调查尿液 3-苯氧基苯甲酸（3-PBA）浓度对韩国代表性成人人群血液参数的影响。我们分析了 6296 名参加韩国国家环境健康调查（2012-2014 年）的成年人的数据。我们采用多元线性回归分析评估了尿 3-PBA 水平与八种血液特征之间的关系：白细胞（WBC）、红细胞（RBC）、血红蛋白、血细胞比容、血小板、平均红细胞体积（MCV）、平均红细胞血红蛋白（MCH）和平均红细胞血红蛋白浓度（MCHC）。尿 3-PBA 水平与 WBC、RBC 和血红蛋白水平呈负相关，与 MCV 水平呈正相关。3-PBA 与血液参数之间的关联方向和程度因性别和年龄而异。3-PBA 对血液参数的不良影响在 60 岁及以上的男性中具有独特性。在该年龄组中，3-PBA 水平与男性的 WBC、RBC、血红蛋白、血细胞比容和 MCHC 水平呈负相关。本研究首次证实，在韩国人群中发现的尿液 3-PBA 浓度与血液参数有关。这一发现值得进一步研究，以了解 3-PBA 对人类血液功能和公共健康的影响。
