Department of Life Science and Bioinformatics, Assam University, Silchar, India.
Department of Human Physiology, Ambedkar College, Fatikroy, Tripura, India.
Adv Exp Med Biol. 2022;1358:141-163. doi: 10.1007/978-3-030-89340-8_7.
Male infertility is one of the major challenging and prevalent diseases having diverse etiologies of which bacteriospermia play a significant role. It has been estimated that approximately 15% of all infertility cases are due to infections caused by uropathogens and in most of the cases bacteria are involved in infection and inflammation leading to the development of bacteriospermia. In response to bacterial load, excess infiltration of leukocytes in the urogenital tract occurs and concomitantly generates oxidative stress (OS). Bacteria may induce infertility either by directly interacting with sperm or by generating reactive oxygen species (ROS) and impair sperm parameters such as motility, volume, capacitation, hyperactivation. They may also induce apoptosis leading to sperm death. Acute bacteriospermia is related with another clinical condition called leukocytospermia and both compromise male fertility potential by OS-mediated damage to sperm leading to male infertility. However, bacteriospermia as a clinical condition as well as the mechanism of action remains poorly understood, necessitating further research in order to understand the role of individual bacterial species and their impact in male infertility.
男性不育症是一种主要的挑战和普遍存在的疾病，其病因多种多样，其中菌精症起着重要作用。据估计，所有不育病例中约有 15%是由尿路病原体引起的感染引起的，在大多数情况下，细菌参与感染和炎症，导致菌精症的发展。为了应对细菌负荷，泌尿生殖道中白细胞的过度浸润会同时产生氧化应激（OS）。细菌可能通过直接与精子相互作用或通过产生活性氧（ROS）并损害精子参数（如运动能力、体积、获能、超激活）来导致不育。它们还可能诱导细胞凋亡导致精子死亡。急性菌精症与另一种称为白细胞精子症的临床病症有关，这两种病症都会通过 OS 对精子造成损害从而导致男性不育，从而降低男性生育能力。然而，菌精症作为一种临床病症以及其作用机制仍未得到充分理解，需要进一步研究以了解个别细菌种类及其对男性不育的影响。
