Key Laboratory of Central CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, P. R. China.
College of Life Science and Technology, Jinan University, Guangzhou, 510632, P. R. China.
Adv Sci (Weinh). 2022 Aug;9(24):e2105731. doi: 10.1002/advs.202105731. Epub 2022 Jun 1.
Physical exercise is effective in alleviating mental disorders by improving synaptic transmission; however, the link between body endurance training and neural adaptation has not yet been completely resolved. In this study, the authors investigated the role of RNA N -methyladenosine (m6A), an emerging epigenetic mechanism, in improved resilience against chronic restraint stress. A combination of molecular, behavioral, and in vivo recording data demonstrates exercise-mediated restoration of m6A in the mouse medial prefrontal cortex, whose activity is potentiated to exert anxiolytic effects. Furthermore, it is revealed that hepatic biosynthesis of one methyl donor is necessary for exercise to improve brain RNA m6A to counteract environmental stress. This novel liver-brain axis provides an explanation for brain network changes upon exercise training and provides new insights into the diagnosis and treatment of anxiety disorders.
体育锻炼通过改善突触传递来有效缓解精神障碍；然而，身体耐力训练与神经适应性之间的联系尚未完全解决。在这项研究中，作者研究了 RNA N -甲基腺苷（m6A）这一新兴的表观遗传机制在提高对慢性束缚应激的恢复力方面的作用。分子、行为和体内记录数据的综合表明，运动介导了小鼠前额叶皮质中 m6A 的恢复，其活动增强，从而产生抗焦虑作用。此外，研究还揭示了肝生物合成一种甲基供体对于运动改善大脑 RNA m6A 以对抗环境压力是必要的。这个新的肝脑轴为运动训练时大脑网络变化提供了一种解释，并为焦虑症的诊断和治疗提供了新的思路。
