Pei Wenhui, Deng Junping, Wang Peng, Wang Xucai, Zheng Liming, Zhang Yangheng, Huang Caoxing
Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China.
State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
Int J Biol Macromol. 2022 Jul 1;212:547-560. doi: 10.1016/j.ijbiomac.2022.05.152. Epub 2022 May 26.
Lignin, the most abundant natural and sustainable phenolic compound in biomass, has exhibited medicinal values due to its biological activities decided by physicochemical properties. Recently, the lignin and its derivatives (such as lignosulfonates and lignosulfonate) have been proven efficient in regulating cellular process and the extracellular microenvironment, which has been regarded as the key factor in disease progression. In orthopaedic diseases, especially the degenerative diseases represented by osteoarthritis and osteoporosis, excessive activated inflammation has been proven as a key stage in the pathological process. Due to the excellent biocompatibility, antibacterial and antioxidative activities of lignin and its derivatives, they have been applied to stimulate cells and restore the uncoupling bone remodeling in the degenerative orthopaedic diseases. However, there is a lack of a systemic review to state the current research actuality of lignin and lignin-derived compounds in treating degenerative orthopaedic diseases. Herein, we summarized the current application of lignin and lignin-derived compounds in orthopaedic diseases and proposed their possible therapeutic mechanism in treating degenerative orthopaedic diseases. It is hoped this work could guide the future preparation of lignin/lignin-derived drugs and implants as available therapeutic strategies for clinically degenerative orthopaedic diseases.
木质素是生物质中最丰富的天然且可持续的酚类化合物，由于其由物理化学性质决定的生物活性而展现出药用价值。最近，木质素及其衍生物（如木质素磺酸盐）已被证明在调节细胞过程和细胞外微环境方面具有成效，而这被视为疾病进展的关键因素。在骨科疾病中，尤其是以骨关节炎和骨质疏松症为代表的退行性疾病，过度激活的炎症已被证明是病理过程中的关键阶段。由于木质素及其衍生物具有出色的生物相容性、抗菌和抗氧化活性，它们已被应用于刺激细胞，并在退行性骨科疾病中恢复解偶联的骨重塑。然而，目前缺乏一项系统性综述来阐述木质素及其衍生化合物在治疗退行性骨科疾病方面的研究现状。在此，我们总结了木质素及其衍生化合物在骨科疾病中的当前应用，并提出了它们在治疗退行性骨科疾病中的可能治疗机制。希望这项工作能够指导未来木质素/木质素衍生药物和植入物的制备，作为临床上退行性骨科疾病的可用治疗策略。
