School of Nursing, Xi'an Jiaotong University Health Science Centre, No. 76 Yanta West Road, Xi'an, 710061, Shaanxi, China.
Surgical Breast Cancer Department, The Tumor Hospital of Shaanxi Province, No. 309 Yanta West Road, Xi'an, 710061, Shaanxi, China.
BMC Womens Health. 2022 May 28;22(1):198. doi: 10.1186/s12905-022-01783-1.
Breast cancer may impair health-related quality of life (HRQoL). We examined the mediating roles of perceived social support (PSS) and coping style (CS) in the relationship between resilience and HRQoL in newly diagnosed breast cancer patients.
Following a cross-sectional design, 431 patients completed a survey at two hospitals in Shaanxi Province, China. Four validated self-report measures assessed HRQoL, psychological resilience, PSS, and CS. A one-sample t-test analyzed differences between resilience, PSS, and CS in breast cancer patients and the corresponding norm. Multivariate linear regression analyzed the independent predictors of HRQoL. The mediating roles of PSS and CS between resilience and HRQoL were investigated using structural equation modeling (SEM).
Participants had significantly lower scores for resilience and PSS, and higher scores for the avoidance and resignation CSs than their corresponding norm. SEM analysis showed resilience had significant direct effects on PSS (Bs: 0.59, 95% CI 0.49, 0.68, P = 0.003), CS (confrontation: 0.53 (0.44, 0.62), P = 0.001; resignation: - 0.66 (- 0.74, - 0.57), P = 0.002), and HRQoL (Bs range from 0.44 to 0.63, P < 0.05). Resilience had significant indirect effects (Bs range from 0.09 to 0.27), and PSS and CS had significant direct effects on HRQoL (P < 0.05).
Newly diagnosed breast cancer patients had lower resilience and PSS, and higher negative CSs, suggesting that PSS and CS mediated the influence of resilience on HRQoL. A multimodal intervention program focusing on PSS and CS might improve the positive influences of resilience on HRQoL in breast cancer patients.
乳腺癌可能会影响健康相关生活质量（HRQoL）。我们研究了在新诊断的乳腺癌患者中，韧性与 HRQoL 之间的关系中，感知社会支持（PSS）和应对方式（CS）的中介作用。
采用横断面设计，431 名患者在中国陕西省的两家医院完成了一项调查。四项经过验证的自我报告措施评估了 HRQoL、心理韧性、PSS 和 CS。采用单样本 t 检验分析了乳腺癌患者与相应常模之间的韧性、PSS 和 CS 的差异。采用多元线性回归分析 HRQoL 的独立预测因子。采用结构方程模型（SEM）研究了 PSS 和 CS 在韧性与 HRQoL 之间的中介作用。
参与者的韧性和 PSS 得分明显较低，回避和屈从应对方式的得分明显较高，与相应的常模相比。SEM 分析表明，韧性对 PSS（Bs：0.59，95%CI 0.49，0.68，P=0.003）、CS（应对：0.53（0.44，0.62），P=0.001；屈从：-0.66（-0.74，-0.57），P=0.002）和 HRQoL（Bs 范围为 0.44 至 0.63，P<0.05）有显著直接影响。韧性具有显著的间接影响（Bs 范围为 0.09 至 0.27），PSS 和 CS 对 HRQoL 有显著的直接影响（P<0.05）。
新诊断的乳腺癌患者的韧性和 PSS 较低，负面应对方式较高，这表明 PSS 和 CS 介导了韧性对 HRQoL 的影响。关注 PSS 和 CS 的多模式干预计划可能会改善乳腺癌患者韧性对 HRQoL 的积极影响。
