Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India.
Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India.
Biomed Pharmacother. 2022 Jul;151:113178. doi: 10.1016/j.biopha.2022.113178. Epub 2022 May 24.
Obesity-related metabolic dysfunction, endothelium imbalance, chronic inflammation, immune dysregulation, and its comorbidities may all have a role in systemic inflammation, leading to the pulmonary fibrosis and cytokine storm, which leads to failure of lung function, which is a hallmark of severe SARS-CoV-2 infection. Obesity may also disrupt the function of mucociliary escalators and cooperation of epithelial cell's motile cilia in the airway, limiting the clearance of the coronavirus that causes severe acute respiratory syndrome (SARS-CoV-2). Adipose tissues in obese patients have a greater number of proteases and receptors for SARS-CoV-2 admittance, proposing that they could serve as an accelerator and reservoir for this virus, boosting immunological response and systemic inflammation. Lastly, anti-inflammatory cytokines such as anti-IL-6 and the infusion of mesenchymal stem cells could be used as a modulation therapy of immunity to help COVID-19 patients. Obesity, on the other hand, is linked to the progress of COVID-19 through a variety of molecular pathways, and obese people are part of the SARS-CoV-2 susceptible individuals, necessitating more protective measures.
肥胖相关的代谢功能障碍、内皮失衡、慢性炎症、免疫失调及其合并症，都可能在全身炎症中发挥作用，导致肺纤维化和细胞因子风暴，进而导致肺功能衰竭，这是严重 SARS-CoV-2 感染的标志。肥胖还可能破坏气道中黏液纤毛清除系统和上皮细胞纤毛的协同运动功能，限制导致严重急性呼吸综合征（SARS-CoV-2）的冠状病毒的清除。肥胖患者的脂肪组织中具有更多的 SARS-CoV-2 进入的蛋白酶和受体，这表明它们可能成为该病毒的加速器和储存库，增强免疫反应和全身炎症。最后，抗炎症细胞因子如抗-IL-6 和间充质干细胞输注可作为 COVID-19 患者免疫调节治疗的手段。另一方面，肥胖通过多种分子途径与 COVID-19 的进展有关，肥胖人群属于 SARS-CoV-2 的易感人群，需要采取更多的保护措施。
