Pitsin D, Polonov K, Penev P, Chernev K
Vutr Boles. 1986;25(6):73-7.
The quantity of the main lipid classes in hepatic tissue has been determined via thin layer chromatography on silica gel, the tissue obtained by blind hepatic biopsy in 20 patients with diabetes mellitus and obesity and in a control group of 5 patients with no hepatic disease. A considerable increase of lipid in liver was established in the patients with diabetes mellitus and obesity-the fraction of neutral lipids mainly. The fatty infiltration of liver in diabetics was accompanied by a considerable increase of triglyceride concentration--3,78 g/100 g wet body mass as compared with the controls--0,95 g/100 g wet body mass. Increased concentration of esters and cholesterol (80%) was established in the liver of the patients with diabetes and obesity as well as increased fraction of free fatty acids (230%). The concentrations of total phospholipids and free cholesterol in liver in both groups of patients proved to be rather close. The fatty infiltration of liver of diabetics with obesity was accompanied by marked increase of percentage content of triglycerides--from 17.3% in the control group to 42.1% from the total lipids in the patients with diabetes and obesity. Reverse alterations were established for the fraction of total phospholipids. Pronounced increase of the coefficient triglycerides/total phospholipids was established in case of diabetes and obesity.
通过硅胶薄层层析法测定了20例糖尿病合并肥胖患者及5例无肝脏疾病的对照组患者经盲法肝活检获取的肝组织中主要脂质类别的含量。糖尿病合并肥胖患者肝脏中的脂质显著增加，主要是中性脂质部分。糖尿病患者肝脏的脂肪浸润伴随着甘油三酯浓度的显著增加——与对照组相比，糖尿病合并肥胖患者为3.78 g/100 g湿体重，而对照组为0,95 g/100 g湿体重。糖尿病合并肥胖患者肝脏中酯类和胆固醇浓度增加（80%），游离脂肪酸比例也增加（230%）。两组患者肝脏中总磷脂和游离胆固醇的浓度相当接近。糖尿病合并肥胖患者肝脏的脂肪浸润伴随着甘油三酯百分比含量的显著增加——从对照组的17.3%增加到糖尿病合并肥胖患者总脂质中的42.1%。总磷脂部分出现相反变化。糖尿病和肥胖患者的甘油三酯/总磷脂系数显著增加。
