CHRU-Nancy, Laboratoire de Virologie, Nancy, F-54000, France.
CHRU-Nancy, Service de Maladies Infectieuses et Tropicales, Nancy, F-54000, France.
Infect Dis Health. 2022 Nov;27(4):203-210. doi: 10.1016/j.idh.2022.05.002. Epub 2022 May 17.
Exposure of healthcare workers (HCW) to SARS-CoV-2 is a public health concern. Not only are HCWs particularly exposed to SARS-CoV-2, but their contamination can also weaken the healthcare system.
We analyzed exposure of French University Hospital HCWs to SARS-CoV-2 through history of positive RT-PCR test and SARS-CoV-2 seroprevalence. Potential risk factors, such as age, BMI, having children or not, working in a COVID-19 unit, or smoking were explored.
From May to June 2020, among the 8960 employees of the University Hospital of Nancy, a serological test was performed in 4696 HCWs. The average (SD) age was 40.4 (11.4) years, and the sample included 3926 women (83.6%). Of the 4696 HCWs, 1050 were smokers (22.4%). Among them, 2231 HCWs had a history of COVID-19 symptoms and/or flu-like syndrome (47.5%) and 238 were seropositive (5.1%). Neither gender, sex, BMI, nor having children were associated with a history of positive RT-PCR test or seropositive status. Previous work in a COVID-19 unit was associated with a history of positive RT-PCR test (p = 0.045), but not with seroprevalence (p = 0.215). As expected, history of COVID-19 clinical manifestations was more frequent in HCWs with positive serology than in HCWs with negative serology (adjusted OR = 1.9, 95%CI [1.4-2.5], p < 0.001). Less expected, smoking was associated with a reduced risk of seropositivity among HCWs (adjusted OR = 0.6, 95%CI [0.4-0.9], p = 0.019).
HCW are patently exposed to SARS-CoV-2. Care to COVID-19 patients was not associated with a higher SARS-CoV-2 seroprevalence. Smoking appears here associated to a lower seroprevalence.
医护人员（HCW）暴露于 SARS-CoV-2 是一个公共卫生关注点。医护人员不仅特别容易接触到 SARS-CoV-2，而且他们的污染还会削弱医疗体系。
我们通过 RT-PCR 检测阳性史和 SARS-CoV-2 血清阳性率分析了法国大学医院 HCW 接触 SARS-CoV-2 的情况。探讨了年龄、BMI、是否有子女、在 COVID-19 病房工作或吸烟等潜在危险因素。
2020 年 5 月至 6 月，在南锡大学医院的 8960 名员工中，对 4696 名 HCW 进行了血清学检测。平均（SD）年龄为 40.4（11.4）岁，样本包括 3926 名女性（83.6%）。在 4696 名 HCW 中，有 1050 人有 COVID-19 症状和/或流感样综合征史（47.5%），238 人血清阳性（5.1%）。性别、性别、BMI 或是否有子女均与 RT-PCR 检测阳性史或血清阳性状态无关。以前在 COVID-19 病房工作与 RT-PCR 检测阳性史相关（p=0.045），但与血清阳性率无关（p=0.215）。如预期的那样，在血清学阳性的 HCW 中，有 COVID-19 临床表现的病史更为常见，而在血清学阴性的 HCW 中则较少见（调整后的 OR=1.9，95%CI [1.4-2.5]，p<0.001）。出乎意料的是，吸烟与 HCW 的血清学阴性率降低相关（调整后的 OR=0.6，95%CI [0.4-0.9]，p=0.019）。
HCW 显然接触到了 SARS-CoV-2。对 COVID-19 患者的护理与 SARS-CoV-2 血清阳性率无相关性。在此，吸烟与较低的血清阳性率有关。
