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用于增强耐腐蚀性和骨再生的氢氧化物涂层PEO处理镁合金

Oxyhydroxide-Coated PEO-Treated Mg Alloy for Enhanced Corrosion Resistance and Bone Regeneration.

作者信息

Xie Juning, Cheng Shi, Zhong Guoqing, Zhou Ruixiang, Zhang Chi, He Yue, Zhang Yu, Peng Feng

机构信息

School of Medicine, South China University of Technology, Guangzhou 510006, China.

Medical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.

出版信息

J Funct Biomater. 2022 May 1;13(2):50. doi: 10.3390/jfb13020050.

DOI:10.3390/jfb13020050
PMID:35645258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9149893/
Abstract

Plasma electrolytic oxidation (PEO) is widely used as a surface modification method to enhance the corrosion resistance of Mg alloy, the most likely applied biodegradable material used in orthopedic implants. However, the pores and cracks easily formed on the PEO surface are unfavorable for long-term corrosion resistance. In this study, to solve this problem, we used simple immersion processes to construct Mn and Fe oxyhydroxide duplex layers on the PEO-treated AZ31 (PEO-Mn/Fe). As control groups, single Mn and Fe oxyhydroxide layers were also fabricated on PEO (denoted as PEO-Mn and PEO-Fe, respectively). PEO-Mn showed a similar porous morphology to the PEO sample. However, the PEO-Fe and PEO-Mn/Fe films completely sealed the pores on the PEO surfaces, and no cracks were observed even after the samples were immersed in water for 7 days. Compared with PEO, PEO-Mn, and PEO-Fe, PEO-Mn/Fe exhibited a significantly lower self-corrosion current, suggesting better corrosion resistance. In vitro C3H10T1/2 cell culture showed that PEO-Fe/Mn promoted the best cell growth, alkaline phosphatase activity, and bone-related gene expression. Furthermore, the rat femur implantation experiment showed that PEO-Fe/Mn-coated Mg showed the best bone regeneration and osteointegration abilities. Owing to enhanced corrosion resistance and osteogenesis, the PEO-Fe/Mn film on Mg alloy is promising for orthopedic applications.

摘要

等离子体电解氧化（PEO）作为一种表面改性方法被广泛应用于提高镁合金的耐腐蚀性，镁合金是骨科植入物中最有可能应用的可生物降解材料。然而，PEO表面容易形成的孔隙和裂纹不利于长期耐腐蚀性。在本研究中，为了解决这个问题，我们采用简单的浸泡工艺在经PEO处理的AZ31（PEO-Mn/Fe）上构建了氢氧化锰和氢氧化铁双相层。作为对照组，还分别在PEO上制备了单一的氢氧化锰和氢氧化铁层（分别表示为PEO-Mn和PEO-Fe）。PEO-Mn呈现出与PEO样品相似的多孔形态。然而，PEO-Fe和PEO-Mn/Fe膜完全封闭了PEO表面的孔隙，即使在样品浸泡在水中7天后也未观察到裂纹。与PEO、PEO-Mn和PEO-Fe相比，PEO-Mn/Fe表现出显著更低的自腐蚀电流，表明其具有更好的耐腐蚀性。体外C3H10T1/2细胞培养表明，PEO-Fe/Mn促进了最佳的细胞生长、碱性磷酸酶活性和骨相关基因表达。此外，大鼠股骨植入实验表明，涂覆有PEO-Fe/Mn的镁表现出最佳的骨再生和骨整合能力。由于耐腐蚀性和骨生成能力的增强，镁合金上的PEO-Fe/Mn膜在骨科应用中具有广阔前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbae/9149893/179a055a5c8d/jfb-13-00050-g008.jpg
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