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用于心肌梗死后心脏修复的自体骨髓单个核细胞（BMMC）相关抗炎纳米颗粒

Autologous Bone Marrow Mononuclear Cells (BMMC)-Associated Anti-Inflammatory Nanoparticles for Cardiac Repair after Myocardial Infarction.

作者信息

Uemura Laercio, Baggio Simeoni Rossana, Bispo Machado Júnior Paulo André, Gavazzoni Blume Gustavo, Kremer Gamba Luize, Sgarbossa Tonial Murilo, Baggio Simeoni Paulo Ricardo, Stadler Tasca Ribeiro Victoria, Silvestre Rodrigo, de Carvalho Katherine Athayde Teixeira, Napimoga Marcelo Henrique, Cesar Francisco Júlio, Guarita-Souza Luiz Cesar

机构信息

Experimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), 1555 Imaculada Conceição Street, Curitiba 80215-901, Brazil.

Instituto de Radiologia (InRad), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05508-070, Brazil.

出版信息

J Funct Biomater. 2022 May 13;13(2):59. doi: 10.3390/jfb13020059.

DOI:10.3390/jfb13020059
PMID:35645267
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9149818/
Abstract

To investigate the effect of transplantation of stem cells from the bone marrow mononuclear cells (BMMC) associated with 15d-PGJ2-loaded nanoparticles in a rat model of chronic MI. Chronic myocardial infarction (MI) was induced by the ligation of the left anterior descending artery in 40 male Wistar rats. After surgery, we transplanted bone marrow associated with 15d-PGJ2-loaded nanoparticle by intramyocardial injection (10 cells/per injection) seven days post-MI. Myocardial infarction was confirmed by echocardiography, and histological analyses of infarct morphology, gap junctions, and angiogenesis were obtained. Our results from immunohistochemical analyses demonstrated the presence of angiogenesis identified in the transplanted region and that there was significant expression of connexin-43 gap junctions, showing a more effective electrical and mechanical integration of the host myocardium. This study suggests that the application of nanoparticle technology in the prevention and treatment of MI is an emerging field and can be a strategy for cardiac repair.

摘要

为研究负载15d -前列腺素J2的纳米颗粒与骨髓单个核细胞（BMMC）联合移植在大鼠慢性心肌梗死模型中的作用。通过结扎40只雄性Wistar大鼠的左前降支诱导慢性心肌梗死（MI）。术后，在心肌梗死后7天通过心肌内注射（每次注射10个细胞）移植负载15d -前列腺素J2的纳米颗粒与骨髓。通过超声心动图确认心肌梗死，并对梗死形态、缝隙连接和血管生成进行组织学分析。我们免疫组织化学分析的结果表明，在移植区域存在血管生成，并且连接蛋白43缝隙连接有显著表达，表明宿主心肌的电和机械整合更有效。本研究表明，纳米颗粒技术在心肌梗死预防和治疗中的应用是一个新兴领域，并且可以成为心脏修复的一种策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f19/9149818/23252de3130d/jfb-13-00059-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f19/9149818/55c45987141c/jfb-13-00059-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f19/9149818/07bb9c170cba/jfb-13-00059-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f19/9149818/fd7e2991d0bd/jfb-13-00059-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f19/9149818/a0c47945c404/jfb-13-00059-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f19/9149818/abc3e8cf8241/jfb-13-00059-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f19/9149818/23252de3130d/jfb-13-00059-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f19/9149818/55c45987141c/jfb-13-00059-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f19/9149818/07bb9c170cba/jfb-13-00059-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f19/9149818/fd7e2991d0bd/jfb-13-00059-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f19/9149818/a0c47945c404/jfb-13-00059-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f19/9149818/abc3e8cf8241/jfb-13-00059-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f19/9149818/23252de3130d/jfb-13-00059-g002.jpg

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