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骨髓源性干细胞群体受甲状腺或/和卵巢激素缺失的差异调控。

Bone Marrow-Derived Stem Cell Populations Are Differentially Regulated by Thyroid or/and Ovarian Hormone Loss.

机构信息

Cell Therapy and Biotechnology in Regenerative Medicine Department, The Pelé Pequeno Príncipe Institute, Child and Adolescent Health Research & Pequeno Príncipe Faculty, Ave. Silva Jardim 1632, Box 80.250-200 Curitiba, Paraná, Brazil.

Feinberg School of Medicine, Feinberg Cardiovascular Research Institute, Northwestern University, 303 E. Chicago Ave., Tarry 14-725, Chicago, IL 60611, USA.

出版信息

Int J Mol Sci. 2017 Oct 19;18(10):2139. doi: 10.3390/ijms18102139.

DOI:10.3390/ijms18102139
PMID:29048335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5666821/
Abstract

Bone marrow-derived stem cells (BMDSCs) play an essential role in organ repair and regeneration. The molecular mechanisms by which hormones control BMDSCs proliferation and differentiation are unclear. Our aim in this study was to investigate how a lack of ovarian or/and thyroid hormones affects stem cell number in bone marrow lineage. To examine the effect of thyroid or/and ovarian hormones on the proliferative activity of BMDSCs, we removed the thyroid or/and the ovaries of adult female rats. An absence of ovarian and thyroid hormones was confirmed by Pap staining and Thyroid Stimulating Hormone (TSH) measurement, respectively. To obtain the stem cells from the bone marrow, we punctured the iliac crest, and aspirated and isolated cells by using a density gradient. Specific markers were used by cytometry to identify the different BMDSCs types: endothelial progenitor cells (EPCs), precursor B cells/pro-B cells, and mesenchymal stem cells (MSCs). Interestingly, our results showed that hypothyroidism caused a significant increase in the percentage of EPCs, whereas a lack of ovarian hormones significantly increased the precursor B cells/pro-B cells. Moreover, the removal of both glands led to increased MSCs. In conclusion, both ovarian and thyroid hormones appear to have key and diverse roles in regulating the proliferation of cells populations of the bone marrow.

摘要

骨髓源性干细胞（BMDSCs）在器官修复和再生中发挥着重要作用。激素控制 BMDSCs 增殖和分化的分子机制尚不清楚。我们在这项研究中的目的是研究卵巢和/或甲状腺激素缺乏如何影响骨髓谱系中的干细胞数量。为了研究甲状腺和/或卵巢激素对 BMDSCs 增殖活性的影响，我们去除了成年雌性大鼠的甲状腺和/或卵巢。通过巴氏染色和促甲状腺激素（TSH）测量分别确认了卵巢和甲状腺激素的缺乏。为了从骨髓中获得干细胞，我们穿刺髂嵴，通过密度梯度抽吸和分离细胞。通过细胞术使用特定标记物来鉴定不同的 BMDSCs 类型：内皮祖细胞（EPCs）、前 B 细胞/祖 B 细胞和间充质干细胞（MSCs）。有趣的是，我们的结果表明，甲状腺功能减退症导致 EPCs 的百分比显著增加，而卵巢激素缺乏则显著增加了前 B 细胞/祖 B 细胞。此外，两个腺体的切除导致 MSCs 增加。总之，卵巢和甲状腺激素似乎在调节骨髓细胞群体的增殖方面具有关键和多样化的作用。

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