Fang Yuan, Li Haibo, Chen Jingting, Xiong Yao, Li Xu, Zhou Jianda, Li Shengli, Wang Shoubao, Sun Binbin
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.
Front Bioeng Biotechnol. 2022 May 13;10:845345. doi: 10.3389/fbioe.2022.845345. eCollection 2022.
Postoperative wound edema, infection, and pain burden the patient's life. Therefore, the purpose of this study is to develop an effective antibacterial, multifunctional application to prevent postoperative edema and relieve postoperative pain by making full use of the dehydrating and analgesic effects of magnesium sulfate (MgSO), magnesium oxide (MgO), sodium alginate (SA), and sodium carboxymethyl cellulose (Na-CMC) to make a composite hydrogel, which can promote postoperative detumescence. MgSO/MgO/SA/Na-CMC composite hydrogel dressings have outstanding mechanical properties, high water absorption, and good biocompatibility. MgO endows the hydrogel dressing with excellent antibacterial properties and better antibacterial activity against common bacteria and multidrug-resistant bacteria. In addition, MgSO/MgO/SA/Na-CMC hydrogel dressing shows superior dehydration and analgesic properties in the postoperative nude mice model. This study shows that the multifunctional MgSO/MgO/SA/Na-CMC composite hydrogel dressing developed as a surgical incision dressing has broad prospects in the prevention of incision infection, postoperative edema, and analgesia.
术后伤口水肿、感染和疼痛给患者的生活带来负担。因此，本研究的目的是开发一种有效的抗菌多功能制剂，通过充分利用硫酸镁（MgSO）、氧化镁（MgO）、海藻酸钠（SA）和羧甲基纤维素钠（Na-CMC）的脱水和止痛作用制成复合水凝胶，以预防术后水肿并缓解术后疼痛，从而促进术后消肿。MgSO/MgO/SA/Na-CMC复合水凝胶敷料具有出色的机械性能、高吸水性和良好的生物相容性。MgO赋予水凝胶敷料优异的抗菌性能，对常见细菌和多重耐药菌具有更好的抗菌活性。此外，MgSO/MgO/SA/Na-CMC水凝胶敷料在术后裸鼠模型中显示出优异的脱水和止痛性能。本研究表明，开发的多功能MgSO/MgO/SA/Na-CMC复合水凝胶敷料作为手术切口敷料在预防切口感染、术后水肿和止痛方面具有广阔前景。
