载锌三氧化二硼纳米纤维增强仿生海藻酸钠水凝胶用于抗菌创伤敷料。
Zn-loaded TOBC nanofiber-reinforced biomimetic calcium alginate hydrogel for antibacterial wound dressing.
机构信息
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China.
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China.
出版信息
Int J Biol Macromol. 2020 Jan 15;143:235-242. doi: 10.1016/j.ijbiomac.2019.12.046. Epub 2019 Dec 6.
Calcium alginate hydrogel dressing is an excellent hydrogel dressing because of its excellent absorption characteristics and tear-free pain. However, its application is limited by its poor mechanical properties and non-bacterial properties. Here, we reported a new biomimetic hydrogel dressing with good mechanical properties and antibacterial properties by 2,2,6,6-tetramethylpiperidine-1-oxyl oxidized bacterial cellulose (TOBC) intensified and a simple method for loading Zn. The results indicated that the mechanical properties were obviously improved by adding 20 wt% TOBC due to the formation of conjoined-network structure. When the concentration of Zn is controlled at about 0.0001 wt%, the hydrogel has good antimicrobial and biological properties. This study provides a simple and sufficient method to prepare new biomimetic antimicrobial hydrogel dressings with good properties.
海藻酸钙水凝胶敷料具有优异的吸水性和无痛性，是一种优秀的水凝胶敷料。然而，其较差的机械性能和非抗菌性限制了其应用。在这里，我们报道了一种新的仿生水凝胶敷料，通过 2,2,6,6-四甲基哌啶-1-氧自由基氧化细菌纤维素（TOBC）增强和简单的载锌方法，具有良好的机械性能和抗菌性能。结果表明，由于形成了联合网络结构，添加 20wt%TOBC 可明显提高力学性能。当 Zn 浓度控制在约 0.0001wt%时，水凝胶具有良好的抗菌和生物性能。本研究为制备具有良好性能的新型仿生抗菌水凝胶敷料提供了一种简单而充分的方法。
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