School of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China.
Department of Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
ACS Appl Mater Interfaces. 2021 Nov 3;13(43):50836-50850. doi: 10.1021/acsami.1c18088. Epub 2021 Oct 24.
Polyetheretherketone (PEEK) is a biocompatible polymer, but its clinical application is largely limited due to its inert surface. To solve this problem, a multifunctional PEEK implant is urgently fabricated. In this work, a dual-metal-organic framework (Zn-Mg-MOF74) coating is bonded to PEEK using a mussel-inspired polydopamine interlayer to prepare the coating, and then, dexamethasone (DEX) is loaded on the coating surface. The PEEK surface with the multifunctional coating provides superior hydrophilicity and favorable stability and forms an alkaline microenvironment when Mg, Zn, 2,5-dihydroxyterephthalic acid, and DEX are released due to the coating degradation. results showed that the multifunctional coating has strong antibacterial ability against both and ; it also improves human umbilical vein endothelial cell angiogenic ability and enhances rat bone marrow mesenchymal stem cell osteogenic differentiation activity. Furthermore, the rat subcutaneous infection model, chicken chorioallantoic membrane model, and rat femoral drilling model verify that the PEEK implant coated with the multifunctional coating has strong antibacterial and angiogenic ability and promotes the formation of new bone around the implant with a stronger bone-implant interface. Our findings indicate that DEX loaded on the Zn-Mg-MOF74 coating-modified PEEK implant with bacteriostasis, angiogenesis, and osteogenesis properties has great clinical application potential as bone graft materials.
聚醚醚酮（PEEK）是一种生物相容性聚合物，但由于其惰性表面，其临床应用受到很大限制。为了解决这个问题，迫切需要制备一种多功能 PEEK 植入物。在这项工作中，使用贻贝启发的聚多巴胺夹层将双金属有机骨架（Zn-Mg-MOF74）涂层结合到 PEEK 上，以制备涂层，然后在涂层表面加载地塞米松（DEX）。具有多功能涂层的 PEEK 表面提供了优异的亲水性和良好的稳定性，并且由于涂层降解，Mg、Zn、2,5-二羟基对苯二甲酸和 DEX 的释放形成了碱性微环境。结果表明，多功能涂层对 和 均具有很强的抗菌能力；它还提高了人脐静脉内皮细胞的血管生成能力，并增强了大鼠骨髓间充质干细胞的成骨分化活性。此外，大鼠皮下感染模型、鸡胚尿囊膜模型和大鼠股骨钻孔模型验证了涂有多功能涂层的 PEEK 植入物具有很强的抗菌和血管生成能力，并促进了植入物周围新骨的形成，具有更强的骨-植入物界面。我们的研究结果表明，具有抑菌、血管生成和成骨特性的负载 DEX 的 Zn-Mg-MOF74 涂层改性 PEEK 植入物作为骨移植物材料具有巨大的临床应用潜力。
