Huang Yangxi, Lin Yufeng, Zhai Xiaobing, Cheng Long
The Nursing School, Nanjing Medical University, Nanjing, China.
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Front Cardiovasc Med. 2022 May 13;9:834150. doi: 10.3389/fcvm.2022.834150. eCollection 2022.
Few prospective studies explored the association of beta-2-microglobulin (B2M) with coronary heart disease (CHD) mortality. The primary objective of this study was to examine the association of serum B2M with CHD and all-cause mortality. This is a prospective cohort study of a nationally representative sample of 4,885 adults, aged 40-85 years, who participated in the National Health and Nutrition Examination Survey (NHANES III) from 1988 to 1994. The relationships between B2M and CHD and all-cause mortality were estimated using Cox proportional hazards regression models. During a median follow-up of 15.5 years, 845 CHD and 3,388 all-cause deaths occurred among 4,885 participants [2,568 women (55.7%); mean (S.D.) age, 66.4 (12.5) years], respectively. In the unadjusted model, B2M concentration was strongly linearly associated with CHD and all-cause mortality (-trend < 0.001). After adjusting multivariable factors, a positive linear association between B2M and all-cause mortality was still observed (H.R. for Q4 vs. Q1 5.90; 95% CI: 5.31-6.57; -trend < 0.001). In the multivariable adjustment model, B2M was significantly associated with an increased risk of CHD mortality (H.R. for Q4 vs. Q1 2.72; 95% CI: 2.07-3.57; -trend < 0.001). In the stratified analyses, the associations of B2M with CHD and all-cause mortality varied by risk factors, such as age, smoking status, and history of hypertension. The findings suggest a significant relationship between the higher serum B2M concentration and increased risk for CHD and all-cause mortality. Further large-scale follow-up studies are also needed to validate this association.
很少有前瞻性研究探讨β2微球蛋白（B2M）与冠心病（CHD）死亡率之间的关联。本研究的主要目的是检验血清B2M与冠心病及全因死亡率之间的关联。这是一项对4885名年龄在40至85岁之间具有全国代表性的成年人进行的前瞻性队列研究，这些人于1988年至1994年参加了国家健康和营养检查调查（NHANES III）。使用Cox比例风险回归模型估计B2M与冠心病及全因死亡率之间的关系。在中位随访15.5年期间，4885名参与者中分别发生了845例冠心病死亡和3388例全因死亡[2568名女性（55.7%）；平均（标准差）年龄为66.4（12.5）岁]。在未调整模型中，B2M浓度与冠心病及全因死亡率呈强线性关联（-趋势<0.001）。在调整多变量因素后，仍观察到B2M与全因死亡率之间呈正线性关联（四分位数4与四分位数1相比的风险比为5.90；95%置信区间：5.31-6.57；-趋势<0.001）。在多变量调整模型中，B2M与冠心病死亡率风险增加显著相关（四分位数4与四分位数1相比的风险比为2.72；95%置信区间：2.07-3.57；-趋势<0.001）。在分层分析中，B2M与冠心病及全因死亡率的关联因年龄、吸烟状况和高血压病史等危险因素而异。研究结果表明，血清B2M浓度升高与冠心病及全因死亡率风险增加之间存在显著关系。还需要进一步的大规模随访研究来验证这种关联。
