低浓度阿托品滴眼液对近视儿童眼光学质量的影响。
Effects of low-concentration atropine eye drops on the optical quality of the eyes in myopic children.
机构信息
Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China.
出版信息
Indian J Ophthalmol. 2022 Jun;70(6):2107-2110. doi: 10.4103/ijo.IJO_2886_21.
PURPOSE
The present study was performed to compare the optical quality of the eyes of myopic children before and after treatment with atropine eye drops of different concentrations.
METHODS
In the study population of 71 patients (131 eyes), 34 patients (63 eyes) were given 0.01% atropine eye drops and 37 patients (68 eyes) were given 0.05% atropine eye drops. The modulation transfer function (MTF) cutoff frequency, Strehl ratio, objective scattering index (OSI), and predicted visual acuities (PVAs 100%, 20%, and 9%) under different lighting conditions were measured before and after two weeks of atropine treatment.
RESULTS
After using 0.05% atropine eye drops for two weeks, the Strehl ratio decreased from 0.27 ± 0.07 to 0.23 ± 0.07 (P = 0.0026), PVA 20% decreased from 1.15 ± 0.32 to 1.03 ± 0.36 (P = 0.0344), and PVA 9% decreased from 0.74 ± 0.23 to 0.64 ± 0.23 (P = 0.0073). The OSI was significantly higher after using 0.05% than 0.01% atropine eye drops (P = 0.0396), while both the Strehl ratio and PVA 20% were lower after using 0.05% than 0.01% atropine eye drops (P = 0.0087 and P = 0.0492, respectively).
CONCLUSION
The children's optical quality did not change significantly after using 0.01% atropine eye drops, whereas it decreased after using 0.05% atropine eye drops.
目的
本研究旨在比较不同浓度阿托品滴眼液治疗近视儿童前后的眼部光质量。
方法
在 71 例患者（131 只眼）的研究人群中，34 例患者（63 只眼）使用 0.01%阿托品滴眼液，37 例患者（68 只眼）使用 0.05%阿托品滴眼液。在两周的阿托品治疗前后，测量不同光照条件下调制传递函数（MTF）截止频率、斯特列尔比、客观散射指数（OSI）和预测视力（100%、20%和 9%的 PVA）。
结果
使用 0.05%阿托品滴眼液两周后，斯特列尔比从 0.27±0.07 降至 0.23±0.07（P=0.0026），20%的 PVA 从 1.15±0.32 降至 1.03±0.36（P=0.0344），9%的 PVA 从 0.74±0.23 降至 0.64±0.23（P=0.0073）。使用 0.05%阿托品后 OSI 显著高于使用 0.01%阿托品（P=0.0396），而使用 0.05%阿托品后斯特列尔比和 20%的 PVA 均低于使用 0.01%阿托品（P=0.0087 和 P=0.0492）。
结论
使用 0.01%阿托品后儿童的光学质量无明显变化，而使用 0.05%阿托品后则下降。
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