Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona ''Istituto Santa Margherita'', University of Pavia, 27100, Pavia, Italy.
Department of Biology, College of Science, University of Bahrain, Sakhir Campus, P.O. Box 32038, Zallaq, Kingdom of Bahrain.
Eat Weight Disord. 2022 Oct;27(7):2701-2711. doi: 10.1007/s40519-022-01412-8. Epub 2022 Jun 1.
Obesity is a chronic disease characterized by a complex variable clinical presentation with comorbidities. A multidisciplinary residential program (MRP) represents one of the best options for treating obesity. The purpose of this study was to evaluate the effectiveness of 8-week MRP on weight loss, body composition assessed by DXA, and metabolic blood parameters between entry (T0) and discharge (T1). The secondary endpoint was the evaluation of the patients' adherence to diet during the check-up outpatient visits, at 2 (T2), 6 (T3), and 12 (T4) months after discharge.
168 subjects were enrolled (61 males and 117 females, aged 58.5 ± 13 years, BMI 41.3 ± 6 kg/m) in the study. The difference in values (end of hospitalization compared to baseline) was calculated through the univariate analysis procedure, which provides regression analysis and analysis of variance for a variable dependent on one or more variables.
There was a statistically significant improvement of all parameters investigated: total mass (- 5.68 kg), fat mass (- 4416.85 g), fat mass index (- 1724.56), visceral adipose tissue (- 332.76 g), arm circumference (- 1.63 cm) and calf circumference (- 1.16 cm). As it is reasonable to expect, even the fat free mass has been reduced (- 1236.03 g); however, the skeletal muscle index was not affected. Statistically significant improvement in glycaemic and lipid profile were reported. The BMI average reduction continued from discharge until T4. No statistically significant changes in fat free mass and visceral adipose tissue (VAT) were reported during a year of follow-up.
The present study demonstrated the clinical benefits of 8-week MRP, which includes hypocaloric diet, physical exercise, and psychological support.
III, evidence obtained from cohort or case-control analytic studies.
肥胖是一种以多种合并症为特征的慢性疾病，其临床表现复杂多变。多学科住院治疗计划（MRP）是治疗肥胖的最佳选择之一。本研究旨在评估 8 周 MRP 对体重减轻、DEXA 评估的身体成分和代谢血液参数的疗效，在入院时（T0）和出院时（T1）进行评估。次要终点是评估患者在出院后 2 个月（T2）、6 个月（T3）和 12 个月（T4）的门诊检查期间对饮食的依从性。
本研究共纳入 168 名受试者（61 名男性和 117 名女性，年龄 58.5±13 岁，BMI 41.3±6kg/m²）。通过单变量分析程序计算（与基线相比住院结束时）值的差异，该程序提供了对一个或多个变量依赖的变量的回归分析和方差分析。
所有研究参数均有统计学意义上的显著改善：总质量（-5.68kg）、脂肪质量（-4416.85g）、脂肪质量指数（-1724.56）、内脏脂肪组织（-332.76g）、臂围（-1.63cm）和小腿围（-1.16cm）。可以合理预期，即使是去脂体重也有所减少（-1236.03g）；然而，骨骼肌指数没有受到影响。报告了血糖和血脂谱的显著改善。从出院到 T4，BMI 的平均降低持续存在。在 1 年的随访期间，去脂体重和内脏脂肪组织（VAT）没有报告统计学上的显著变化。
本研究证明了 8 周 MRP 的临床益处，包括低热量饮食、体育锻炼和心理支持。
III，来源于队列或病例对照分析研究的证据。
