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衰老过程与中枢听觉通路：基于听觉脑干诱发电位和频率跟随反应的研究。

Aging process and central auditory pathway: a study based on auditory brainstem evoked potential and frequency-following response.

机构信息

Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.

Centro de Eletrofisiologia e Neuroaudiologia Avançada, São Paulo, SP, Brazil.

出版信息

Einstein (Sao Paulo). 2022 May 27;20:eAO6829. doi: 10.31744/einstein_journal/2022AO6829. eCollection 2022.

DOI:10.31744/einstein_journal/2022AO6829
PMID:35649058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9126604/
Abstract

OBJECTIVE

To analyze age-related changes in the central auditory pathway in healthy elderly individuals.

METHODS

A prospective, quantitative cross-sectional study. The caseload comprised 18 adults (mean age, 22.78 years) and 18 elderly individuals (mean age, 66.72 years) of both sexes, who met inclusion criteria. Subjects were submitted to basic audiological evaluation and related electrophysiologic tests: brainstem auditory evoked potential with click stimulus and frequency-following response.

RESULTS

Elderly individuals had higher wave and interpeak latencies (waves I, III and V and interpeaks I-V and III-V) of brainstem auditory evoked potential. Latencies of frequency following response waves A, E, F and O were also higher in elderly individuals. Frequency following response amplitudes were better in A than in D, F and O waves in these subjects. Likewise, interpeak intervals (V-A and V-O) were larger in elderly relative to adult individuals. Lower slope values were observed in elderly individuals.

CONCLUSION

Brainstem auditory evoked potential and frequency-following response allowed appropriate assessment of age-related changes in the auditory pathway. Slower neural response to auditory stimuli suggests reduced synchrony between neural structures.

摘要

目的

分析健康老年人中枢听觉通路的年龄相关性变化。

方法

前瞻性、定量的横断面研究。纳入了 18 名成年人（平均年龄 22.78 岁）和 18 名老年人（平均年龄 66.72 岁），所有受试者均符合纳入标准。所有受试者均进行了基本听力学评估和相关电生理测试：短声刺激脑干听觉诱发电位和频率跟随反应。

结果

老年人的脑干听觉诱发电位的波和峰间潜伏期（I、III 和 V 波以及 I-V 和 III-V 峰间潜伏期）较高。老年人的频率跟随反应 A、E、F 和 O 波的潜伏期也较高。在这些受试者中，A 波的频率跟随反应幅度优于 D、F 和 O 波。同样，老年组的 V-A 和 V-O 峰间间期也大于成年组。老年人的斜率值较低。

结论

脑干听觉诱发电位和频率跟随反应可适当评估听觉通路的年龄相关性变化。听觉刺激的神经反应较慢表明神经结构之间的同步性降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2033/9126604/8c8c8c678d1a/2317-6385-eins-20-eAO6829-gf07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2033/9126604/f2cbfaf3c96c/2317-6385-eins-20-eAO6829-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2033/9126604/753bc2162a30/2317-6385-eins-20-eAO6829-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2033/9126604/9215427d56d5/2317-6385-eins-20-eAO6829-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2033/9126604/d9f814900a48/2317-6385-eins-20-eAO6829-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2033/9126604/14fc4fcde986/2317-6385-eins-20-eAO6829-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2033/9126604/08556a4d9a2d/2317-6385-eins-20-eAO6829-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2033/9126604/8c8c8c678d1a/2317-6385-eins-20-eAO6829-gf07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2033/9126604/f2cbfaf3c96c/2317-6385-eins-20-eAO6829-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2033/9126604/753bc2162a30/2317-6385-eins-20-eAO6829-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2033/9126604/9215427d56d5/2317-6385-eins-20-eAO6829-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2033/9126604/d9f814900a48/2317-6385-eins-20-eAO6829-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2033/9126604/14fc4fcde986/2317-6385-eins-20-eAO6829-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2033/9126604/08556a4d9a2d/2317-6385-eins-20-eAO6829-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2033/9126604/8c8c8c678d1a/2317-6385-eins-20-eAO6829-gf07.jpg

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