Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Org Lett. 2022 Jun 10;24(22):3998-4002. doi: 10.1021/acs.orglett.2c01408. Epub 2022 Jun 1.
Pseudonochelin (), a siderophore from a marine-derived sp. bacterium, was discovered using genome mining and metabolomics technologies. A 5-aminosalicylic acid (5-ASA) unit, not previously found in siderophore natural products, was identified in . Annotation of a putative biosynthetic gene cluster combined with bioinformatics and isotopic enrichment studies enabled us to propose the biosynthesis of . Moreover, was found to display and antibacterial activity in an iron-dependent fashion.
假诺卡霉素（）是一种从海洋来源的 细菌中发现的铁载体，使用基因组挖掘和代谢组学技术发现。在 中发现了一个以前在铁载体天然产物中未发现的 5-氨基水杨酸（5-ASA）单元。推定生物合成基因簇的注释结合生物信息学和同位素富集研究，使我们能够提出 的生物合成。此外，发现 以铁依赖性方式表现出 和 抗菌活性。
