Corrao Kristen, Rezwan Siam, Atallah Ehab, Michaelis Laura C, Runaas Lyndsey, Harrington Alexandra M, Abedin Sameem
Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, United States.
Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, United States.
Leuk Res Rep. 2022 May 26;17:100329. doi: 10.1016/j.lrr.2022.100329. eCollection 2022.
OBJECTIVE/BACKGROUND: Low risk myelodysplastic syndrome (MDS) is a marrow failure state eventually leading to transfusion dependence. Flow cytometry has previously been demonstrated as prognostic tool in MDS, however not thoroughly studied in lower risk MDS. In this study, we assessed whether assessment for immunophenotypic blast aberrancies by flow in low risk MDS patients has a prognostic role in these patients.
A total of 63 consecutive patients diagnosed with low/intermediate risk MDS were included. We recorded initial flow results, and collected time to transfusion dependence, and AML progression.
On multivariate cox regression analysis, increasing IPSS-R score, an increase in the number of blast aberrancies on flow cytometry, and aberrant expression of CD7 on myeloid blasts increased likelihood of transfusion dependence.
Low risk MDS patients with increasingly aberrant blast phenotypes by flow may be at risk for earlier transfusion dependence.
目的/背景：低危骨髓增生异常综合征（MDS）是一种最终会导致输血依赖的骨髓衰竭状态。流式细胞术此前已被证明是MDS的一种预后评估工具，但在低危MDS中尚未得到充分研究。在本研究中，我们评估了通过流式细胞术对低危MDS患者进行免疫表型原始细胞异常评估是否对这些患者具有预后作用。
共纳入63例连续诊断为低/中危MDS的患者。我们记录了初始流式细胞术结果，并收集了达到输血依赖的时间以及急性髓系白血病（AML）进展情况。
在多变量Cox回归分析中，国际预后评分系统-修订版（IPSS-R）评分增加、流式细胞术检测到的原始细胞异常数量增加以及髓系原始细胞上CD7的异常表达增加了输血依赖的可能性。
流式细胞术显示原始细胞表型异常程度增加的低危MDS患者可能面临更早出现输血依赖的风险。
