Zhang Yuchen, Shu Tianyu, Wang Silin, Liu Zhongbo, Cheng Yilong, Li Ang, Pei Dandan
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
School of Chemistry, Xi'an Jiaotong University, Xi'an, China.
Front Bioeng Biotechnol. 2022 May 16;10:911180. doi: 10.3389/fbioe.2022.911180. eCollection 2022.
Calcium phosphate (CaP)-based bioceramics are the most widely used synthetic biomaterials for reconstructing damaged bone. Accompanied by bone healing process, implanted materials are gradually degraded while bone ultimately returns to its original geometry and function. In this progress report, we reviewed the complex and tight relationship between the bone healing response and CaP-based biomaterials, with the emphasis on the degradation mechanisms of such material and their osteoinductive properties mediated by immune responses, osteoclastogenesis and osteoblasts. A deep understanding of the interaction between biological healing process and biomaterials will optimize the design of CaP-based biomaterials, and further translate into effective strategies for biomaterials customization.
磷酸钙（CaP）基生物陶瓷是用于修复受损骨骼的应用最为广泛的合成生物材料。随着骨愈合过程的推进，植入材料会逐渐降解，而骨骼最终会恢复其原始的几何形状和功能。在本进展报告中，我们回顾了骨愈合反应与CaP基生物材料之间复杂而紧密的关系，重点关注此类材料的降解机制以及由免疫反应、破骨细胞生成和成骨细胞介导的骨诱导特性。深入了解生物愈合过程与生物材料之间的相互作用，将优化CaP基生物材料的设计，并进一步转化为生物材料定制的有效策略。
