Li Qipeng, Feng Cong, Cao Quanle, Wang Wei, Ma Zihan, Wu Yonghao, He Tinghan, Jing Yangtian, Tan Wenxuan, Liao Tongxiao, Xing Jie, Li Xiangfeng, Wang Ye, Xiao Yumei, Zhu Xiangdong, Zhang Xingdong
College of Chemical Engineering, Sichuan University, Chengdu 610065, China.
National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610065, China.
Regen Biomater. 2023 Feb 17;10:rbad013. doi: 10.1093/rb/rbad013. eCollection 2023.
Calcium phosphate (CaP) bioceramics are widely applied in the bone repairing field attributing to their excellent biological properties, especially osteoinductivity. However, their applications in load-bearing or segmental bone defects are severely restricted by the poor mechanical properties. It is generally considered that it is challenging to improve mechanical and biological properties of CaP bioceramics simultaneously. Up to now, various strategies have been developed to enhance mechanical strengths of CaP ceramics, the achievements in recent researches need to be urgently summarized. In this review, the effective and current means of enhancing mechanical properties of CaP ceramics were comprehensively summarized from the perspectives of fine-grain strengthening, second phase strengthening, and sintering process optimization. What's more, the further improvement of mechanical properties for CaP ceramics was prospectively proposed including heat treatment and biomimetic. Therefore, this review put forward the direction about how to compatibly improve mechanical properties of CaP ceramics, which can provide data and ideas for expanding the range of their clinical applications.
磷酸钙（CaP）生物陶瓷因其优异的生物学性能，尤其是骨诱导性，而被广泛应用于骨修复领域。然而，其在承重或节段性骨缺损中的应用受到较差力学性能的严重限制。一般认为，同时提高CaP生物陶瓷的力学性能和生物学性能具有挑战性。到目前为止，已经开发了各种策略来提高CaP陶瓷的机械强度，迫切需要总结近期研究的成果。在这篇综述中，从细晶强化、第二相强化和烧结工艺优化的角度，全面总结了提高CaP陶瓷力学性能的有效和当前方法。此外，前瞻性地提出了进一步改善CaP陶瓷力学性能的方法，包括热处理和仿生。因此，本综述提出了如何兼容地提高CaP陶瓷力学性能的方向，可为扩大其临床应用范围提供数据和思路。
