Luthman J, Jacobsson S O
Acta Vet Scand. 1986;27(3):313-25. doi: 10.1186/BF03548146.
The penetration of penicillin into tissue cage fluid (TCF) in calves was studied after intravenous and intramuscular injection. The penicillin concentrations in TCF were lower than in serum and maximum was reached much later. Intravenous injection of benzyl-penicillin gave significantly higher levels in TCF than intramuscular injection. The penetration after procaine penicillin was very slow. The results showed that the serum peak rather than the area under curve determines the penetration of penicillin. Repeated intramuscular injections of benzylpenicillin and procaine penicillin caused an accumulation of penicillin in TCF. Similar levels were however reached by one single intravenous injection. The clinical counterparts to the used tissue cage model are abscesses. It was concluded that if high penicillin concentration are desireable in such foci, the drug must be given in a way that gives as high serum peaks as possible.
研究了静脉注射和肌肉注射后青霉素在犊牛组织笼液(TCF)中的渗透情况。TCF中的青霉素浓度低于血清中的浓度,且达到最大值的时间要晚得多。静脉注射苄青霉素后,TCF中的水平明显高于肌肉注射。普鲁卡因青霉素的渗透非常缓慢。结果表明,血清峰值而非曲线下面积决定了青霉素的渗透。重复肌肉注射苄青霉素和普鲁卡因青霉素会导致青霉素在TCF中蓄积。然而,单次静脉注射可达到相似的水平。所用组织笼模型在临床上对应的情况是脓肿。得出的结论是,如果希望在这些病灶中达到高青霉素浓度,则必须以能产生尽可能高血清峰值的方式给药。