局部耐受性对牛和猪体内两种青霉素G制剂药代动力学的影响。
Influence of the local tolerance on the pharmokinetics of two penicillin G preparations in cattle and swine.
作者信息
Luthman J, Dall V, Jacobsson S O, Bengtsson B, Korpe C
出版信息
Acta Vet Scand. 1988;29(2):199-206. doi: 10.1186/BF03548371.
The addition of citrate buffer to a penicillin G preparation for injection was in a preliminary study found to improve the local tolerance in rabbits. In the present study 2 penicillin G preparations with different citrate buffer content was tested in the target species swine and cattle. The results of the local tolerance studies indicated that the preparation with the highest citrate content caused less tissue damage. In swine this preparation gave 100% higher maximum levels in serum than the more tissue irritating preparation. In calves the most irritating preparation showed significantly longer half-life. The results indicated that the local tolerance may influence the serum levels in a way that may influence the penetration of penicillin.
在一项初步研究中发现，向注射用青霉素G制剂中添加柠檬酸盐缓冲液可提高家兔的局部耐受性。在本研究中，对两种不同柠檬酸盐缓冲液含量的青霉素G制剂在目标物种猪和牛身上进行了测试。局部耐受性研究结果表明，柠檬酸盐含量最高的制剂对组织的损伤较小。在猪身上，该制剂的血清最高水平比更具组织刺激性的制剂高100%。在犊牛身上，刺激性最强的制剂半衰期明显更长。结果表明，局部耐受性可能会以影响青霉素渗透的方式影响血清水平。
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