Food Engineering Department, Engineering Faculty, Giresun University, Giresun, Turkey.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2022 Aug;39(8):1474-1486. doi: 10.1080/19440049.2022.2081367. Epub 2022 Jun 2.
Two hundred and two hazelnut paste samples from various hazelnut processing plants in the Black Sea Region of Turkey were analysed for the incidence of aflatoxins (AFs) by liquid chromatography coupled with fluorescence detection (LC-FLD). All 202 (100%) hazelnut paste samples were contaminated with various AFs ranged from 0.17 to 12.96 µg kg. AF contamination level of four (1.98%) samples exceeded legal limits. Risk assessment for hazelnut paste was determined by using AF incidence results, and the margin of exposure (MOE) and hepatocellular carcinoma (HCC) risk approach were applied. For the adult Turkish population (15+ years age group), the average lower bound (LB) and upper bound (UB) exposure levels for aflatoxin B1 (AFB1) and total aflatoxins (AFT) were 0.0106-0.0107 ng kg body weight (bw) per day and 0.0250 ng kg bw per day, respectively. MOE estimates for mean and 95th percentile exposures to AFB1 for hazelnut paste were higher than 10,000, which indicates no potential health concern for Turkish adults. HCC for the Turkish population was 0.00023 cases per 100,000 people per year. The study indicates that Turkish population is not under this toxicological risk when consuming hazelnut paste containing food products.
202 份来自土耳其黑海地区不同榛子加工工厂的榛子酱样本通过液相色谱-荧光检测法（LC-FLD）分析了黄曲霉毒素（AFs）的含量。所有 202 份榛子酱样本均受到了不同程度的 AF 污染，污染范围为 0.17 至 12.96μg/kg。4 份（1.98%）样本的 AF 污染水平超过了法定限量。通过使用 AF 发生率结果对榛子酱进行风险评估，并应用暴露量边际（MOE）和肝细胞癌（HCC）风险方法。对于土耳其成年人（15 岁及以上年龄组），黄曲霉毒素 B1（AFB1）和总黄曲霉毒素（AFT）的平均下限（LB）和上限（UB）暴露水平分别为 0.0106-0.0107ng/kg 体重/天和 0.0250ng/kg bw/天。榛子酱中 AFB1 的平均和 95%分位数暴露的 MOE 估计值高于 10,000，这表明土耳其成年人食用榛子酱不存在潜在的健康问题。土耳其人口的 HCC 为每年每 10 万人中有 0.00023 例。研究表明，当食用含有榛子酱的食品时，土耳其人口不会受到这种毒理学风险的影响。
